摘要
目的探讨CD4+CD25+调节性T细胞在糖尿病合并肺部感染患者免疫机制中的作用。方法 20例糖尿病合并肺部感染患者,于治疗前(DM-P组)及治愈后(DM组)分别用流式细胞仪检测血CD4+、CD4+CD25+,计算CD4+CD25+/CD4+比值,并与20例肺部感染患者(肺部感染组)、30例健康体检者(健康对照组)比较。结果 DM-P组及肺部感染组CD4+CD25+调节性T细胞数量及比值均显著高于健康对照组(P<0.01),DM-P组及DM组CD4+CD25+调节性T细胞数量及比值显著少于肺部感染组(P<0.05)。结论 CD4+CD25+调节性T细胞比例减少可能与糖尿病合并肺部感染者存在免疫缺陷、致炎及抗炎失衡、感染难治愈有关。
Objective To investigate the effect of CD4 ＋ CD25＋ regulatory T cells in the immune mechanism in diabetes mellitus patients complicated with pulmonary infection. Methods The CIM ＋ CD25＋ , CIM ＋ of twenty patients with diabetes mellitus complicated with pulmonary infection before treatment （DM-P group）and post curing（ DM group）, 20 subjects of pulmonary infection （pulmonary infection group）and 30 subjects of normal （normal control group）were measured by flow cytometry, and their CD4 ＋ CD25＋/CD4＋ ratios were calculated. Results The CD4 ＋ CD25 ＋regulatory T cells counts and the ratios of CD4 ＋CD25 ＋/CD4 ＋ in DM-P group and pulmonary infection group were higher than that in normal control group（P 〈0.01 ） ,and the ratios of CD4 ＋ CD25 ＋/CD4 ＋ in DM-P group and DM group were lower than that in pulmonary infection group （P 〈 0.05）. Conclusion The decrease of CD4 ＋CD25 ＋ count may correlated with the immune deficiency, anti-inflammatory disturbance and refractory infection of diabetes mellitus patients complicated with pulmonary infection.
出处
《广西医学》
CAS
2011年第2期162-164,共3页
Guangxi Medical Journal
基金
广西南宁市科学研究与技术开发计划
创新计划项目(南科攻20060168C)
