摘要
目的探讨sCD40/sCD40L在早发型子痫前期的表达及意义。方法采用酶联免疫吸附法测定2008年10月至2009年10月在哈尔滨医科大学附属第一医院住院分娩的早发型子痫前期患者60例(轻度子痫前期和重度子痫前期患者各30例),及随机选取30例正常晚期妊娠孕妇静脉血及脐血中sCD40L的水平。结果 sCD40L在早发型子痫前期患者静脉血及脐血中的表达均高于正常孕妇(P<0.05),而在重度子痫前期患者的静脉血中的表达为(7.67±3.37),脐血中的表达为(8.03±2.70),高于轻度子痫前期患者的静脉血(3.15±2.38)及脐血(5.58±1.94)中的表达,P<0.05,差异有统计学意义。结论 sCD40/sCD40L在早发型子痫前期呈高表达,且与疾病的严重程度相关。sCD40/sCD40L的检测可以为早发型子痫前期的早期发现提供监测指标,甚至为临床选择期待治疗还是终止妊娠提供一定的依据。
Objective To explore the expression of sCD40/sCD40L in early-onset preeclampsia and its significance.Methods The enzyme-linked immunosorbent assay from October 2008 to October 2009 at the First Affiliated Hospital of Harbin Medical University to give birth in patients with early-onset preeclampsia 60 cases,（mild pre-eclampsia 30 cases and severe pre-eclampsia patients 30 cases）,and randomly selected 30 cases of normal late pregnancy in maternal blood and cord blood levels of sCD40L.Results Expression of sCD40L in blood and cord blood in patients with early-onset preeclampsia were higher than that in normal pregnant women（P〈0.05）,the difference was significant,while in patients with severe preeclampsia in the blood（7.67±3.37）,in cord blood expressed as（8.03±2.70） were higher than that in the blood of patients with mild preeclampsia（3.15±2.38） and umbilical cord blood（5.58±1.94）,P〈0.05.Conclusion Expression of sCD40/sCD40L in early-onset preeclampsia is high and associates with the severity of the disease.sCD40/sCD40L test for early-onset preeclampsia provides for early detection,and a basis to choice termination of pregnancy or clinical treatment.
出处
《哈尔滨医科大学学报》
CAS
北大核心
2011年第1期55-57,共3页
Journal of Harbin Medical University
