摘要
研究多巴胺（ＤＡ）与卡托普利（Ｃａｐ）合用对外源性羟自由基（·ＯＨ）灌注所致家兔心肌损伤的治疗效果．结果表明，ｉｖ·ＯＨ生成液后立即静滴ＤＡ１０μｇ·ｋｇ－１·ｍｉｎ－１，３０ｍｉｎ，输注期间心肌收缩能力明显升高，但停药后逐渐恶化．血清脂质过氧化产物丙二醛（ＭＤＡ）含量明显升高，心肌超微结构损伤．Ｃａｐ（给·ＯＨ前２ｍｉｎｉｖ２．５ｍｇ·ｋｇ－１）及Ｃａｐ＋ＤＡ组则保持心功能指标和ＭＤＡ在正常范围，但单独Ｃａｐ组心肌收缩功能指标在开始１５ｍｉｎ有下降趋势．两组心肌细胞超微结构大致正常．结果提示，Ｃａｐ＋ＤＡ联合用药对·ＯＨ所致心功能降低的保护作用优于单独Ｃａｐ治疗，同时克服了单用ＤＡ加重心肌损伤的不足．
The effects of combination of dopamine (DA) and captopril (Cap) on ·OH induced myocardial injury were investigated. After iv·OH solution, a 30 min DA (10 μg·kg 1 ·min 1 ) infusion acutely increased myocardial performance. Myocardial performance after DA administration, however, was significantly depressed. Lipid peroxide malondialdehyde(MDA) in serum was significantly increased. Myocardial ultrastructure was injured. The function of myocardium and MDA in serum were normal in Cap (2.5 mg·kg 1 iv 2 min before ·OH infusion) and Cap+DA combination group, but Cap alone elicited decreasing trend of myocardial contractility during the beginning 15 min period. Myocardial ultrastructure was nearly normal in Cap group and Cap+DA combination group. The results indicate that the combination of Cap and DA is considerd better than Cap alone in terms of the stability of normal cardiac function. Meanwhile, the combination could prevent DA induced myocardial injury.
出处
《中国药理学与毒理学杂志》
CAS
CSCD
北大核心
1999年第3期205-209,共5页
Chinese Journal of Pharmacology and Toxicology
关键词
羟自由基
心肌损伤
卡托普利
多巴胺
hydroxyl radical
myocardial injury
captopril
dopamine
malondialdehyde
