摘要
目的:探讨阿托伐他汀不同剂量对冠心病急性心肌梗死(AMI)伴有心力衰竭患者经皮冠状动脉介入术(PCI)前、后高敏C反应蛋白(hs-CRP)的影响。方法:选取AMI伴心衰拟行PCI患者87例,随机分为低剂量、中剂量、高剂量3组,并分别口服阿托伐他汀10、20、40 mg/d,在PCI前即刻(0 h)、术后12 h、24 h、72 h及4周(4 W)时检测血清hs-CRP水平。结果:3组术后各时间点血清hs-CRP较0 h均明显升高(P均<0.05),并随时间延长有升高趋势,4 W时趋于稳定;高剂量阿托伐他汀能更显著降低血清hs-CRP(P<0.05)。结论:高剂量阿托伐他汀可明显降低AMI伴心衰行PCI患者血清hs-CRP水平,从而减轻机体因PCI促发的炎症反应,期望降低冠脉支架术后再狭窄发生率。
Objective： To explore effect of atorvastatin at different dosage on hs-C-reactive protein（CRP） of patients with acute myocardial infarction（AMI） and heart failure after percutaneous coronary intervention（PCI）.Methods： A total of 87 cases with AMI and heart failure were randomly divided into three groups： low-dosage group,middle-dosage group and high-dosage group.All patients in three groups had oral administration of atorvastatin at 10,20 and 40 mg/d,respectively.The level of hs-CRP in serum were meas the level a tendency. ured before PCI t Oh, hs-CRP w （Oh）, and 12h, 24h, 72h and 4 weeks after surgery. Results ere increased significantly at other times （All P〈0.05） with The level was stable at th nificant （P〈0.05）. Conclusions： tients with AMI and heart failure. e 4th week. Atorvastatin orvastatin at high dosage It can relief inflammation Compared with time-dependent at high dosage decreased hs CRP more sig can significant decrease hs-CRP level of pa reaction due to PCI and is expected to decrease incidence of restenosis.
出处
《海南医学院学报》
CAS
2011年第2期203-205,共3页
Journal of Hainan Medical University
基金
海南医学院科研基金资助学报项目(0020110036)~~
