摘要
目的:探讨妊娠晚期阴道菌群异常与不良妊娠结局的关系。方法:对我院1280例妊娠35周后孕妇产前常规进行阴道假丝酵母菌、滴虫、细菌性阴道病(BV)、衣原体、淋菌检查,部分病例同时行白带需氧菌培养。共筛检出异常患者204例,根据自觉症状有无分为有症状组91例和无症状组113例,同时随机选取200例病原体阴性者做为正常对照组,比较3组不良妊娠结局发生情况。结果:①有症状组与无症状组在胎膜早破、产褥感染、新生儿感染及新生儿黄疸方面差异有统计学意义(P<0.05),而在早产、剖宫产率及胎儿窘迫、低出生体重儿发生率方面差异无统计学意义(P>0.05)。②有症状组与正常对照组相比较,胎膜早破、产褥感染及新生儿感染发生率显著升高(P<0.05),而在早产、剖宫产率、胎儿窘迫、低出生体重儿及新生儿黄疸发生率方面差异无统计学意义(P>0.05)。③无症状组与正常对照组在上述不良母儿结局方面差异均无统计学意义(P>0.05)。结论:妊娠晚期阴道微生态环境异常与不良妊娠结局密切相关,对有自觉症状者尤其更应该进行全面检查和积极治疗,减少不良妊娠结局的发生。
Objective：To investigate the correlation of vaginal flora at late pregnancy and pregnancy outcomes.Methods：1280 cases of pregnant women after 35 gestation weeks in Zhejiang Univercity Affiliated Obstetrics and Gynecology Hospital were recruited. The prenatal vaginal candida,trichomonas,bacterial vaginosis （BV）,chlamydia and gonococcus were checked,some women had vaginal discharge culture for aerobic bacteria. Abnormal pathogenes were found in 204 women,who were divided into two groups：symptomatic group（91 cases） and asymptomatic group（113 cases）,At the same time,200 pregnancy women with negative result were randomly selected as control group. The pregnancy outcomes of these three groups were compared. Results：①Symptomatic group and asymptomatic group had significant differences in premature rupture of membrane,puerperal infection,neonatal infection and neonatal jaundice （P〈0.05）,whilethere were no significant differences in premature delivery,caesarean section rate,fetal distress and incidence of low birth weight infant（P〉0.05）.②The incidence of premature rupture of membrane,puerperal infection and neonatal infection were higher in symptonmatic group than control group（P〈0.05）. While the rates of premature labor,cesarean section,fetal distress,low birth weight infant and neonatal jaundice were not significantly different between these two groups（P〉0.05）.③There were no significant differences in the above adverse pregnancy outcomes between asymptomatic group and control group（P〉0.05）. Conclusions：Abnormal vaginal microbial enviroment at late pregnancy is closely associated with adverse pregnancy outcomes,thus for those pregnant women with symptoms,a comprehensive examination and aggressive treatment to reduce the incidence of adverse pregnancy outcomes are essential.
出处
《实用妇产科杂志》
CAS
CSCD
北大核心
2010年第12期933-935,共3页
Journal of Practical Obstetrics and Gynecology
关键词
阴道微生态
阴道菌群
妊娠结局
Vaginal microbial
Vaginal flora
Pregnancy outcomes
