摘要
目的探讨伊立替康联合氟尿嘧啶时辰化疗治疗晚期结直肠癌的疗效和毒副反应。方法分析我院自2007年6月至2008年12月应用伊立替康联合氟尿嘧啶时辰化疗方案治疗的32例晚期结直肠癌患者的疗效和毒副反应,并与我院同时期应用FOLFIRI方案化疗的31例晚期结直肠癌患者进行比较。结果时辰化疗方案和FOLFIRI方案的总有效率(RR)、疾病控制率(DCR)分别为21.9%、65.6%和25.8%、58.1%。时辰化疗方案的中位疾病进展时间(mTTP)为6.4个月,中位总生存时间(mOS)为9.0个月;FOLFIRI方案的mTTP为5.0个月,mOS为7.9个月,两组比较差异均无统计学意义(P>0.05)。两方案常见的毒副反应为恶心呕吐、中性粒细胞减少和腹泻,但多以1～2级为主;3～4级毒副反应在时辰化疗方案中的发生率低于FOLFIRI方案。结论伊立替康联合氟尿嘧啶时辰化疗方案具有疗效高、毒副作用低等优点,可作为晚期结直肠癌的推荐化疗方案之一。
Objective To evaluate the efficacy and toxicity of irinotecan（CPT-11）in combination with fluorouracil（5-FU）chronochemotherapy in the treatment of patients with advanced colorectal cancer.Methods An analysis in patients with advanced colorectal cancer treated with CPT-11 and 5-FU chronochemotherapy were evaluated from June 2007 to December 2008,which was done compared with the regimen of FOLFIRI.Thirty-two patients in CPT-11 and 5-FU chronochemotherapy group and 31 patients in FOLFIRI group were analyzed.Results The response rate and disease control rate in chronochemotherapy group were 21.9% and 65.6%,whereas in FOLFIRI group were 25.8% and 58.1% respectively.The median overall survival time and the median time to progression were 6.4 months and 9.0 months in chronochemotherapy group,whereas in FOLFIRI group were 5.0 months and 7.9 months.There were no obvious differences between the two groups（P0.05）.The frequent side-effects in the two groups were nausea,vomiting,neutropenia and diarrhea,but most of them were slight（gradeⅠ-Ⅱ）.While in gradeⅢ-Ⅳside effects,the rate of chronochemotherapy group was lower than that in FOLFIRI group.Conclusion The effect in the treatment of advanced colorectal cancer patients with CPT-11 and 5-FU regimen chronochemotherapy are effective,and the side-effects are low.It can be used as a recommended therapy for advanced colorectal cancer.
出处
《临床肿瘤学杂志》
CAS
2010年第12期1103-1106,共4页
Chinese Clinical Oncology
关键词
晚期结直肠癌
时辰化疗
疗效
毒性
Advanced colorectal cancer
Chronochemotherapy
Efficacy
Toxicity
