摘要
目的 探讨乙、丙型肝炎病毒（ＨＢＶ、ＨＣＶ） 重叠感染时，病毒之间的相互作用。方法 检测３０ 例ＨＢＶ、ＨＣＶ重叠感染患者血清病毒标志物的变化、ＨＢＶ前Ｃ区１ ８９６ 位点突变的发生比率及血清肿瘤坏死因子（ＴＮＦ）α、白细胞介素（ＩＬ）６ 含量。结果 与单纯ＨＢＶ或ＨＣＶ 感染者相比，重叠感染患者乙肝表面抗原（ＨＢｅＡｇ） 、ＨＢＶＤＮＡ、ＨＣＶＲＮＡ 阳性比率明显降低，乙肝ｅ 抗体（ 抗ＨＢｅ） 阳性比率明显升高，ＨＢｓＡｇ、抗ＨＢｃ ＩｇＧ 及抗ＨＣＶ 几何平均滴度也明显降低，部分患者ＨＢｓＡｇ 阴转。而ＨＢＶ前Ｃ区１ ８９６ 位点突变发生率及血清ＴＮＦα、ＩＬ６ 含量却明显高于单纯感染者。结论 ＨＢＶ、ＨＣＶ感染同一宿主时，存在相互干扰、抑制；ＨＢｅＡｇ 的消失、抗ＨＢｅ 的阳转既与ＨＣＶ对ＨＢＶ 复制的直接抑制有关，又与ＨＢＶ的前Ｃ区变异有关，且ＨＣＶ 的重叠感染可能是导致ＨＢＶ 前Ｃ区变异的原因之一。
Objective To investigate virus interaction in HBV and HCV superinfection.Methods The changes of serum markers of 30 patients with HBV and HCV superinfetion were observed. Meanwhile, mutation of HBV precore region at nt 1 896 and the amount of TNFα and IL 6 in sera were also investigated.Results Compared with HBV or HCV single infection, positive rates of HBeAg、HBV DNA and HCV RNA in superinfectim were lower, positive rates of anti HBe was higher, the average titers of HBsAg、anti HBcIgG and anti HCV were significantly lower, too. In some patients, HBsAg were seronegatively convested. Occurrence rate of HBV precore region mutation at nt1896 and levels of TNFα and IL 6 in sera were higher in super infection than those in single infection.Conclusion Interference existed between HBV and HCV superinfection, conversion from HBeAg to anti HBe was not only due to the suppression by HCV but also to the mutation of HBV precore region, and HCV may be a reason causing HBV precore region mutation through increasing the pressure of the body′s immunosystem.
出处
《中华实验和临床病毒学杂志》
CAS
CSCD
1999年第3期255-258,共4页
Chinese Journal of Experimental and Clinical Virology
