摘要
目的 建立颅腔闭合的大鼠蛛网膜下腔出血（ＳＡＨ） 模型。方法 经颈外动脉或颈总动脉导入玻璃纤维至颈内动脉颅内段，刺破Ｗｉｌｌｉｓ 环而造成大鼠ＳＡＨ。对ＳＡＨ 组和假手术（ＳＯ） 组检测２４小时内局部脑血流量（ｒＣＢＦ） ，并观察基底动脉（ＢＡ） 管径。结果 在ＳＡＨ 模型大鼠的蛛网膜下腔均发现大量血液或血凝块。ＳＡＨ 后ｒＣＢＦ立即下降，并持续２４ 小时，同时ＢＡ 管径缩小。结论 血管内穿刺法能可靠诱导大鼠ＳＡＨ，并可产生脑血管痉挛。
Objective: To establish a new, noncraniotomy rat subarachnoid hemorrhage (SAH) model. Methods: SAH in rat was produced by introducing a intraluminal glass fibre through external carotid artery or common carotid artery and piercing the Willis cycle. Regional cerebral blood flow (rCBF) within 24 hours was detected and diameter of basilar artery (BA) was observed. Results: Extensive blood or blood clot was found in subarachnoid spaces of all SAH model rats. rCBF was decreased obviously within 24 hours after induction of SAH. Diameter of BA was also decreased markedly after SAH. Conclusion: Endovascular perforation is a reliable method in the induction of rat SAH, which can induce cerebral vasospasm.
出处
《泰山医学院学报》
CAS
1999年第3期202-204,共3页
Journal of Taishan Medical College
关键词
动物模型
蛛网膜下腔出血
脑血管痉挛
animal model
subarachnoid hemorrhage
cerebral vasospasm
rats
