摘要
目的探讨腹腔镜胆囊切除手术时,右美托咪定对二氧化碳气腹期间心血管反应的影响。方法将40例腹腔镜胆囊切除术病人,随机分为对照组(A组)和右美托咪定组(B组),每组20例。A组麻醉诱导后1ml/min静脉泵入生理盐水10ml,B组麻醉诱导后以2μg/kg静脉泵入右美托咪啶,10min泵入。分别在给药前(T0),给药后10 min(T1),气腹时(T2)、气腹后5 min(T3)、15 min(T4)、30 min(T5)测定收缩压(SBP)、舒张压(DBP)、心率(HR),并计算收缩压心率乘积(RPP)。结果对照组气腹期间及气腹后的SBP、DBP、HR和RPP高于充气前,有显著性差异(P<0.05,P<0.01);右美托咪定组气腹期间及气腹后SBP、DBP、HR和RPP与充气前比较,无显著性差异(P>0.05)。两组之间比较,气腹期间及气腹后对照组各参数水平显著高于B组(P<0.05),A组气腹后血压、心率较气腹前均有所升高(P<0.05),B组在T1时SBP、DBP、HR和RPP与T0相比均有所下降(P<0.05),并在T3、T4、T5也明显低于A组(P<0.05)。结论右美托咪定可减轻腹腔镜手术气腹期间的心血管反应。
Objective To observe the effects of dexmedetomidine（Dex） on cardiovascular effects during CO2 pneumoperitoneum in laparoscopic cholecystectom.Methods 40 patients undergoing LC were divided into two groups：A group（intravenous 1ml/min 0.9% NaCl at 10 minutes after anesthesia induction）,B group（intravenous 2μg/kg Dex at 10 minutes after anesthesia induction）.The SBP,DBP,HR were recorded before injection（T0）,at 10 minutes after injection（T1） at the moment of pneumoperitoneum（T2） and 5 minutes（T4）,15 minutes（T5）,30minutes（T5） after pneumoperitoneum respectively.Results In A Group SBP,DBP,HR and RPP during pneumoperitoneum and after pneumoperitoneum were higher than before（P〈0.05）.While in B Group,there was no significant difference in this respect.As for the two groups,SBP,DBP,HR and RPP of A Group were higher than those of B Group.In A group the blood pressure and HR were higher after CO2 pneumoperitoneum than before（P〈0.05）.In B group the blood pressure and HR were lower at T1 than at T0（P〈0.05）,and obviously lower than those of A group at T3,T4,T5（P〈0.05）.Conclusion Intravenous injection ofdexmedetomidine can alleviate cardiovascular effects during CO2 pneumoperitoneum laparoscopic surgery.
出处
《湖北民族学院学报（医学版）》
2011年第1期43-44,47,共3页
Journal of Hubei Minzu University(Medical Edition)
