摘要
目的 探讨肝细胞生长因子的第一个Kringle结构域（HGFK1）在肝细胞癌中的表达及其临床意义.方法 采用免疫组化EnVision法检测HGFK1在58例原发性肝癌患者手术切除标本中的表达,并进一步分析HGFKI表达与患者临床病理生理特征和预后的关系.结果 HGFK1的高表达与患者的年龄、性别、术前甲胎蛋白水平、肿瘤大小以及Child分级无关（P ＞0.05）,但与病理分级和门脉癌栓形成显著相关（P＜0.01）.病理分级差（Edmondson分级Ⅲ～Ⅳ级）、有门脉癌栓形成、3年复发的患者,其HGFK1高表达率均明显降低（P＜0.05或0.01）.HGFK1高表达患者5年生存率明显高于HGFK1低表达患者（P＜0.05）.结论 HGFK1的表达与肝细胞癌患者病理分级、有无门脉癌栓形成、3年复发与否及5年生存率相关,而与患者年龄、性别、术前甲胎蛋白水平、肿瘤大小以及Child分级等临床特征无明显关系.
Objective To investigate the expression and clinical significance of HGFK1 （the kringle 1 domain of human hepatocyte growth factor）in hepatocellular carcinoma （HCC）. Methods The expression of HGFKI was detected by EnVision im- munohistochemistry in 58 HCC tissue specimens. The correlation of HGFKI expression with clinical and pathological features of HCC patients was analyzed. Results In patients with poor pathological grade （Edmondson grade III N IV level）, portal vein tumor thrombus formation and 3-year recurrence the expression rate of HGFK1 was lower （P〈0.05 or P〈0.01 ）; and the 5-Year survival rate of patients with high HGFK1 expression was significantly higher than that with low HGFK1 expression （P〈0.05）. The expression of HGFK1 was not associated with age, sex, preoperative AFP level, tumor size and Child classification of HCC patients （P 〉0.05）.Conclusion The expression of HGFK1 is correlated with the pathological grade and prognosis of HCC patients.
出处
《浙江医学》
CAS
2011年第3期307-308,311,共3页
Zhejiang Medical Journal
基金
基金项目：浙江省自然科学基金项目（Y207028）
浙江省科技厅项目（2009C33SA800006）
关键词
肝细胞癌
HGFK1
门脉癌栓
Hepabocellular carcinoma HGFK1 Portal vein tumor thrombus
