摘要
目的:寻找HIV-1M组基因最佳构建进化树的分型方法。方法:从Genbank中筛选出对各成熟肽区域有注释来源,来自于不同国家地区的104条HIV-1M组全基因组序列。对序列的结构区域ENV区分别建ML、MP、NJ系统进化树。结果:ML、MP、NJ能对HIV-1M组正确分型。结论:ML、MP、NJ能对HIV-1M组正确分型,但因NJ操作简便快捷,推荐为HIV-1M组分型最佳方法。
Objective：To find a best bioinformatics tool for typing HIV-1M subtype.Methods：104 complete genome sequences of HIV-1 M group which had been given the annotation about every region and derived from different countries were downloaded from Genebank.Phylogenetic trees on ENV region were established by ML、MP、NJ method.Results：The typing result of the HIV-1M group is right by the three methods.Conclusion：No major differences were found among the variables studied.Because NJ method is more simple and quick than MP and ML method,NJ is the best bioinformatics tool for typing HIV-1M subtype.
出处
《泸州医学院学报》
2011年第2期134-138,共5页
Journal of Luzhou Medical College
