摘要
目的:检测P物质(SP)在口腔扁平苔藓(OLP)组织中的表达,探讨SP与OLP的关系。方法:采用免疫组织化学技术检测19例口腔扁平苔藓和正常人口腔黏膜组织中SP的表达。结果:比较OLP组和正常对照组SP的表达,差异有统计学意义(P<0.05),SP在OLP病损组织中表达高于正常黏膜组织;比较SP在糜烂型OLP组与非糜烂型OLP组的表达,差异无统计学意义(P>0.05)。结论:SP在OLP组织中表达增高,SP在OLP的发生发展中可能参与了淋巴细胞的浸润及增殖,并参与了OLP慢性炎症机制。
Objective：To examine the expression of substance P（SP） in Oral lichen planus（OLP） lesion and investigate the association between SP and OLP.Methods：SP expression was examined in 19 OLP and 19 normal mucosa tissues by IHC.Results：The difference of SP expression in OLP and normal mucosal tissues was significant（P0.05）：the SP expression level was higher in OLP tissues than in normal mucosa tissues.The difference of SP expression in erosive OLP and non-erosive OLP group was not significant（P0.05）.Conclusions：The expression of neuropeptides SP was increased in OLP tissues,suggesting that SP might be involved in infiltration and proliferation of lymphocytes in pathogenesis of OLP,and SP might participate in chronic inflammatory mechanisms of OLP.
出处
《泸州医学院学报》
2011年第2期150-152,共3页
Journal of Luzhou Medical College
关键词
口腔扁平苔藓
P物质
免疫组织化学
Oral lichen planus（OLP）
substance P（SP）
immumohistochemistry（IHC）
