摘要
目的探讨乙型肝炎病毒相关性肾炎(hepatitis B virus-associated glomerulonephritis,HBV-GN)易感性与乙型肝炎病毒(HBV)CP区基因变异的关系。方法选择19例HBV-GN为实验组,22例慢性HBV感染者为对照组,应用基因测序技术检测HBV血浆CP区基因位点的变异。结果 CP区中nt1727和nt1773位点HBV-GN组的变异率显著高于HBV组(100%和59.1%,47.4%和13.6%,P<0.05)。nt1762/1764联合变异率在两组中的差别无统计学意义(P>0.05)。结论 HBV-GN易感性可能与HBV的CP区基因变异有关。
Objective To study the correlation of hepatitis B virus（HBV） in the core promoter regions gene mutations in patients with hepatitis B virus associated glomerulonephritis（HBV-GN）.Methods Nineteen patients of HBV-GN were chosen as experimental group and 22 patients of chronic hepatitis B（CHB） as control group.Gene mutations of HBV were detected by complete genome sequences technique in the core promoter/precore regions.Results In the core promoter regions,the prevalence of the nt1727 and nt1773 mutations patients were significantly higher in the HBV-GN group than in the CHB group（100%vs 59.1%,and 47.4%vs 13.6%,P0.05）.The prevalence of the nt1762/1764 mutation was not significantly different between the HBV-GN group and the CHB group（P0.05）.Conclusion There maybe relationships between HBV in the core promoter regions gene mutations and HBV-GN.
出处
《哈尔滨医科大学学报》
CAS
北大核心
2010年第6期553-555,共3页
Journal of Harbin Medical University
基金
黑龙江省自然科学基金资助项目(080620)
关键词
乙型肝炎病毒
乙型肝炎相关性肾炎
基因变异
hepatitis B virus
hepatitis B virus-associated glomerulonephritis
gene mutation
