摘要
背景:脊髓损伤后组织的再生和功能的恢复一直是神经外科及康复医师面临的重大难题。数十年来大量的动物实验证实通过干细胞移植对脊髓损伤有一定的修复作用,并开展了临床试验,但并未取得满意的疗效。目的:综述近年干细胞移植治疗脊髓损伤的进展及面临的问题,为干细胞治疗脊髓损伤的进一步研究指明方向,促进脊髓损伤患者的康复。方法:应用计算机检索维普、万方和PubMed数据库中1990-01/2010-03关于干细胞治疗脊髓损伤的文章,在标题和摘要中以"脊髓损伤;干细胞;移植;机制;临床应用"或"Spinalcord injury;stem cells;transplantation;mechanism;clinic alapplication"为检索词进行检索,初检得到285篇文献,根据纳入和排除标准选择30篇文章进行综述。结果与结论:据纳入和排除标准共纳入综述30篇文章,通过阅读及收集相关信息,对干细胞移植治疗脊髓损伤的基本机制、干细胞的来源及选择、干细胞的移植方式、移植次数、干细胞移植治疗脊髓损伤的临床应用现状等进行了总结,并提出目前面临的问题。干细胞移植治疗脊髓损伤有着巨大的发展潜力,但同时也存在一些问题,而这些问题将是干细胞治疗脊髓损伤的进一步研究的方向。
BACKGROUND：Tissue regeneration and functional recovery after spinal cord injury（SCI） have always been a significant challenge for neurosurgeon and rehabilitation physicians.For decades,a lot of animal experiments have confirmed that stem cell transplantation had certain repair effects on SCI,and had made many clinical trials,but did not obtain satisfactory effects.OBJECTIVE：To review recent advances and problems in stem cell transplantation for SCI,so as to point the way for further studies,and to promote recovery of SCI patients.METHODS：We retrieved articles about therapy of stem cell for SCI in Vip,Wanfang and PubMed databases for articles published from January 1990 to March 2010.The key words were ＂spinal cord injury,stem cells,transplantation,mechanism,clinical application＂ for retrieval in the title and abstracts.A total of 285 articles were primarily obtained,and 30 articles were included for this review in accordance with inclusion criteria and exclusion criteria.RESULTS AND CONCLUSION：According to the inclusion and exclusion criteria,we got 30 articles.Through reading and collecting information,we summarized the basic mechanisms of stem cell transplantation for treating SCI,sources and selection of stem cells,transplantation methods,transplantation frequency and the clinical status,and put forward the problems at present.Stem cell transplantation for SCI is a great potential treatment,but some problems also exist.These problems will be the direction of further research addressing stem cell therapy for SCI.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2010年第49期9294-9297,共4页
Journal of Clinical Rehabilitative Tissue Engineering Research
