摘要
目的探讨中国居民高尿酸血症与代谢综合征组分关联性并定量评价关联的大小,为预防及临床治疗提供依据。方法通过检索我国1999—2010年发表的关于高尿酸血症与代谢综合征关系的病例-对照研究文献,进行定量综合分析,运用RevMan 4.2进行合并和异质性检验,根据异质性检验结果选择固定效应模型或随机效应模型,计算合并WMD或OR值及95%CI。结果共纳入11篇文献,连续性变量合并WMD值及95%CI分别为,BMI的WMD值=1.66(95%CI:1.45～1.86);高三酰甘油的WMD值=0.86(95%CI:0.80～0.92);HDL-C的WMD值=0.08(95%CI:-0.05～0.20);分类变量合并OR值及95%CI为:高血压的OR值=2.77(95%CI:2.20～3.48);高血糖的OR值=2.28(95%CI:1.79～2.92)。结论除HDL-C外,高尿酸血症与代谢综合征的组分相关联。
Objective To investigate the correlation of hyperuricemia with the risk of metabolic syndrome in Chinese population and provide evidence for prevention and therapy of metabolic syndrome. Methods The case-control studies published during 1999 to 2010 were analyzed synthetically and quantitatively by Meta-analysis method with Review Manager 4.2 software. According to homogeneity test results, fixed or random effect models were chosen to calculate the pooled-WMD or OR and 95%CI. Results 11 studies were included; the pooled-WMD and 95%C! for continuous variables were 1.66 （95%CI：1.45-1.86） for BMI, 0.86 （95%CI：0.80-0.92） for hypertriglyceridemia, and 0.08 （95%CI：-0.05-0.20） for HDL-C; the pooled-OR and 95%CI for categorical variables were 2.77 （95%CI：2.20-3.48） for hypertension and 2.28 （95%CI： 1.79-2.92） for hyperglycaemia respectively. Conclusion Except HDL-C, hyperuricemia may be associated with other components of metabolic syndrome in Chinese population.
出处
《中国慢性病预防与控制》
CAS
北大核心
2011年第2期154-156,共3页
Chinese Journal of Prevention and Control of Chronic Diseases
基金
天津市卫生局重点科技攻关项目(07KG4)
