摘要
目的:探讨各种浓度高渗盐水对重型颅脑外伤后脑水肿患者,降低颅内压,提高脑灌注压的效果。方法:选择我院160例患者,按照应用高渗盐水的浓度不同,分为四组,每组各40例,持续监测患者平均动脉压、颅内压,比较各组之间对于降低颅内压,提高脑灌注压的效果。结果:7.5%HS组颅内压降低幅度高于另外三组(P<0.05),7.5%HS组平均动脉压明显高于其他三组(P<0.05),7.5%HS组颅内压明显低于其他三组(P<0.05),7.5%HS组患者脑灌注压明显高于其他三组(P<0.05)。结论:四种不同浓度的高渗盐水,在降低脑外伤后脑水肿患者颅内压、提高脑灌注压方面均有一定效果,其中以7.5%HS效果最佳。
Objective： To explore the various concentrations of hypertonic saline on brain edema in patients with severe head trauma, increased intracranial pressure, cerebral perfusion pressure. Method： 160 patients, according to the different concentrations of hypertonic saline, were divided into 4 groups, each with 40 cases, continuous monitoring of patients with mean arterial pressure, intracranial pressure, comparing each group to reduce intracranial pressure enhance the effect of cerebral perfusion pressure. Result： 7.5% HS group rate of intracranial pressure was lower than the other three groups （ P〈0.05 ）, 7.5% HS group rate of the average arterial pressure was significantly higher than the other three groups （ P〈0.05 ）, 7.5% HS group rate of intracranial pressure was significantly lower than the other three groups （ P〈0.05 ）, 7.5% HS group rate of cerebral perfusion pressure was significantly higher than the other three groups （ P〈0.05 ）. Conclusion： Four different concentrations of hypertonic saline can reduce brain edema after traumatic brain injury patients with intracranial pressure, increase cerebral perfusion pressure, but 7.5% HS is the best of all.
出处
《河北医学》
CAS
2011年第4期434-437,共4页
Hebei Medicine
基金
广东省深圳市宝安区科技计划项目:201003361
关键词
高渗盐水
脑外伤
颅内压
脑灌注压
Hypertonic saline
Brain injury
Intracranial pressure
Cerebral perfusion pressure
