摘要
目的探讨瞬时弹性记录仪（FS）测定肝脏硬度值对肝纤维化诊断价值。方法对112例入院诊断为慢性乙型肝炎（CHB）的患者行肝穿刺,诊断肝脏纤维化;放射免疫法检测血清HA、LN、PCⅢ、ⅣC的水平;用FS诊断仪探测CHB患者肝脏硬度值（LSM）,并与肝脏的组织学纤维化分期（S）进行比较和相关性分析。结果 112例CHB患者LSM均值为（14.23±8.11）kPa,肝纤维化S3期的LSM值（13.41±5.94）kPa,肝纤维化S4期的LSM值（16.25±8.09）kPa,且LSM值随纤维化分期从S0~S4期逐步升高,LSM及HA与肝脏纤维化分期呈显著正相关（r=0.896,P〈0.01;r=0.724,P〈0.01）;患者血清C-Ⅳ、LN、PⅢNP 3项与肝脏纤维化分期也呈正相关,但差异无统计学意义。结论 FS检测慢性肝病患者肝纤维化程度稳定性良好,是一种无创、无痛、快速、客观定量检测肝纤维化的有效方法,LSM值可以作为判断肝纤维化的程度及抗纤维化疗效的参考指标。
Objective To study the value of the instantaneous elastic recorder（FibroScan,FS） for detecting liver stiffness in the diagnosis of liver fibrosis.Methods 112 cases of chronic hepatitis B（CHB） were performed the liver biopsy for diagnosing liver fibrosis.The radioimmunoassay（RIA） was used to detect HA,LN,PⅢ,C-Ⅳ.FS was adopted to detect the liver hardness（LSM）.The results were compared with the liver fibrosis histological stage（S） and performed the relativity analysis.Results The mean LSM in 112 cases of CHB was（14.23±8.11）kPa,which was（13.41±5.94）kPa in liver fibrosis stage S3 and（16.25±8.09）kPa in liver fibrosis stage S4.The value of LSM was gradually increased from the liver fibrosis stage S0 to S4,showing that LSM was positively correlated with the liver fibrosis staging（r=0.896,P001;r=0.724,P0.01）.The three indexes of serum C-Ⅳ,LN and PⅢ were also positively correlated with the liver fibrosis staging,but there was no statistical significance.Conclusion FS has good stability for detecting liver fibrosis,which is a noninvasive,painless,rapid and effective method for objective and quantitative detection of live fibrosis.LSM value may be used as the reference index for judging the degree of liver fibrosis and curative effects of antifibrosis.
出处
《重庆医学》
CAS
CSCD
北大核心
2011年第13期1285-1286,1288,共3页
Chongqing medicine
关键词
肝硬化
病理学
血清学
瞬时弹性记录仪
liver cirrhosis
pathology
serology
instantaneous elastic recorder（FibroScan
FS）
