摘要
目的比较腹腔镜胆囊切除术（LC）与开腹胆囊切除术（OC）对机体激素反应的影响。方法选60例作择期胆囊切除术的病人，40例LC，20例OC，分别于术前1d，手术结束时，术后第1、2、3d采血，测定促肾上腺皮质激素（ACTH）、皮质醇（F）、肾上腺素（E）、去甲肾上腺素（NE）、催乳激素（PRL）和胰岛素的浓度变化。结果ACTH、F、E、NE、PRL在手术结束时达最高值，较术前显著升高（P＜0．01，P＜0．05）；ACTH和F浓度在术后第1d，E在术后第1、2d，NE在手术结束时和术后第2d，OC组明显高于LC组。结论LC和OC都可以引起明显的激素反应，OC组反应持续时间长，恢复慢。
Objective To compare the neuroendocrine responses to laparoscopic and open cholecystectomy. Methods The selective cholecystectomy had been performed on sixty patients, among which 40 cases underwent laparoscopic cholecystectomy as LC groups, 20 cases open cholecystectomy as OC group. Blood samples were taken one day before surgeryl at the end of the operations as well as on the lst, Znd and 3rd postoperativedays in both groups seperately. The changes of ACTH, cortisol(F), epinephrine(E), norepinephrine (NE), prolactin(PRL) and insulin were determined and compared. Results The concentration of ACTH, F, E, NE and PRL reached their peak values at the end of the operations which was statistically higher (P<0.05 or P<0.01) than that of preoperative ones in both groups respectively. The vaules of ACTH and F on the lst day after surgery, E on the lst, Znd days after surgery, NE at the end of surgery and on the Znd postoperative day in OC group were significantly higher than that of those hormones during the same periods in LC group. Conclusion Both LC and OC would induce the neuroendocrine responses of body, while it was longer and more severe in OC.
出处
《上海第二医科大学学报》
CSCD
1999年第4期343-345,共3页
Acta Universitatis Medicinalis Secondae Shanghai
基金
上海市科委资助
上海市卫生局资助!954119027
关键词
腹腔镜术
胆囊切除术
激素反应
laparoscopy
cholecystectomy
hormonal responses
