摘要
目的:研究3-甲氧基-4-O-(2'-亚甲基-3'5'6'-三甲基吡嗪基)肉桂酸(MC-002)抗高血压治疗对大鼠脑卒中的保护作用。方法:采用双肾一夹(2K1C)法复制RHRSP(stroke prone renovascular hypertensive rats)模型引发肾性高血压,高钠饮水进一步加速脑卒中形成。观察MC-002各剂量组静脉注射给药后对脑卒中大鼠神经症状、体重、血压、脑组织病理切片的影响。结果:MC-002能明显改善大鼠的神经症状,显著降低大鼠的血压(P<0.01 vs模型组);30、18 mg/kg剂量组能显著抑制脑卒中大鼠的体重下降(P<0.01vs模型组);脑组织病理切片显示,治疗组神经细胞形态和数目均得到显著改善。结论:MC-002作为一种新型的Ca2+拮抗剂和自由基清除剂,抗高血压治疗对大鼠脑卒中具有明显的保护作用。
AIM： To investgate the protection effects of 3-methoxy-4-O-（2＇-methyl radical-3＇5＇6＇-trimethyl pyrazinyl） cinnamic acid（MC-002） on anti-stroke in rats by antihypertensive therapy. METHODS： RHRSP（stroke prone renovascular hypertensive rats） model was reproduced to initiate 2K1C renal hypertension,and the stroke was accelerated by high sodium intake.The effect of MC-002 at different doses on rats＇ neurological symptom,body weight,blood pressure and pathological section of brain tissues were examined after the administration by i.v.injections.RESULTS：MC-002 can significantly improve the rats＇ neurological symptom and decrease blood pressure（P0.01）;MC-002（30 and 18 mg/kg） can markedly inhibit the dropping of rats＇ bodyweight（P0.01）;the pathological observations showed that neuronal cells shape and number were obviously improved after treated with MC-002.CONCLUSION： As a new Ca2＋ antagonist and scavenger of free radicals,MC-002 has notable effects of stroke protection in rats by antihypertensive therapy.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2011年第2期139-143,共5页
Chinese Journal of Clinical Pharmacology and Therapeutics
基金
十一五重大专项课题(2009ZX09103-123)
