摘要
目的:优化去氢骆驼蓬碱固体脂质纳米粒(HM-SLN)的制备工艺。方法:以包封率、载药量及稳定性为评价指标,采用正交试验法优选处方和制备工艺,并对优选条件下制得的HM-SLN进行质量评价。结果:以优化处方制备的去氢骆驼蓬碱固体脂质纳米粒平均粒径为121nm,包封率为(88.11±0.585)%,载药量为(2.03±0.005)%。结论:本优化工艺制备HM-SLN包封率较高,稳定性好,方法可靠。
Objective： To prepare the Harmine solid lipid nanoparticles（HM-SLN）.Methods：The preparation of HM-SLN was optimized by orthogonal design with the encapsulate efficiency（EE%）,drug loading（DL%） and stability as evaluation parameters.Then the quality of the obtained HM-SLN was determinated.Results：The obtained HM-SLN had even with a mean diameter of 121 nm,the encapsulate efficiency ratio and the drug loading of the prepared HM-SLN was（88.11±0.585）% and（2.03±0.005）%.Conclusion：The entrapment ratio of HM-SLN is high and the stability is good for HM-SLN prepared by twice high shear ultrasound method,and the method is reliable.
出处
《农垦医学》
2010年第6期487-489,共3页
Journal of Nongken Medicine
基金
石河子大学医学院第一附属医院科研起动资金专项(Yy2007-25)
