摘要
目的观察扶中升白方对大肠癌化疗所致白细胞减少的治疗作用。方法选择有明确病理学诊断的大肠癌患者60例并随机分为2组,对照组30例以草酸铂、氟尿嘧啶和亚叶酸钙为基础的化疗方案治疗;治疗组30例在对照组治疗的同时,化疗间歇期给予扶中升白方。6个疗程及全疗程结束后1个月观察患者的白细胞、红细胞、血红蛋白、血小板计数,记录粒细胞集落刺激因子使用量、中医症候积分、生存质量评分以及肝肾功能等指标。结果与对照组比较,治疗组大肠癌患者因化疗所致白细胞减少的出现时间明显延长,白细胞减少程度降低,化疗后白细胞和血红蛋白恢复加快,粒细胞集落刺激因子使用剂量减少,血红蛋白减少,中医症候得以改善,并减轻了化疗对大肠癌患者生存质量的影响和对机体的损伤,且安全低毒。结论扶中升白方是治疗大肠癌患者化疗所致白细胞减少的有效、安全、低毒中药小复方制剂。
Objective It is to observe the efficacy of little compound preparation Fuzhong Shengbai（FZSB） decoction in treatment of neutropenia induced by colorectal cancer chemotherapy.Methods 60 patients with malignancies confirmed by pathology or cytology were randomly divided into two groups,there were 30 cases in each group.The cases in control group were given chemotherapy regimen based on Oxaliplatin plus Leucovorin plus Fluorouracil.The cases in treatment group were given FZSB decoction combined with chemotherapy regimen,and FZSB decoction was given between two periods of chemotherapy.All six periods of chemotherapy treatment and the countercheck one month after the whole periods were observed.The change of leucocyte counts,the dosage of using granulocyte colony stimulating factor,the erythrocyte and hemoglobin and thrombocyte counts,the score of traditional Chinese medicine symptom,Karnofsky performance status were observed,also the function of the liver and kidney were observed as safety index.Results Compared with control group,the time of chemotherapy induced neutropenia was delayed,the degree of neutropenia was reduced,the resume of leucocyte and hemoglobin were improved after the whole periods of chemotherapy,the dosage of using Granulocyte-colony stimulating factor was decreased,the degree of hypoglobulia was reduced,the score of traditional Chinese medicine symptom was increased,and the damnification on the body taken by chemotherapy was reliefed in treatment group. Conclusion FZSB decoction is a little compound safety preparation which is effective on treating chemotherapy induced neutropenia.
出处
《现代中西医结合杂志》
CAS
2011年第15期1821-1823,共3页
Modern Journal of Integrated Traditional Chinese and Western Medicine
基金
上海市卫生局中医药科研基金(2008L035C)
上海市中医临床优势专科建设项目(2008YSZK003)
关键词
扶中升白方
大肠癌
化疗
白细胞减少
Fuzheng Shengbai decoction
colorectal cancer
chemotherapy
neutropenia
