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开郁清热方对脂联素及胰岛分泌的影响 被引量:5

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摘要 目的观察开郁清热方对脂联素及胰岛素分泌的影响,研究开郁清热方对胰岛功能保护的作用机制。方法选择INS-1细胞,通过高糖高脂造成β细胞功能衰竭模型,分别给予开郁清热方含药血清大、中、小剂量,并给予罗格列酮作为对照,观察各组胰岛素分泌及脂联素的变化。结果开郁清热方能够促进高糖环境下胰岛素的分泌(P<0.05),并具有剂量依赖性,剂量越大越能促进胰岛素分泌,并且可以升高脂联素含量。结论开郁清热方可以通过升高起到胰岛功能保护的作用。
出处 《北京中医药》 2011年第4期310-312,共3页 Beijing Journal of Traditional Chinese Medicine
基金 国家自然科学基金青年基金项目(81001513)
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