摘要
目的应用光学相干断层成像（OCT）对比不同类型药物洗脱支架（DES）置人后的内膜覆盖情况。方法人选62例在我院置人DES（15．3±5．7）个月后行OCT检查的患者，依据置人支架类型分为Cypher支架组（病例数=26，支架数=57）、Endeavor支架组（病例数=17，支架数：23）和Firebird支架组（病例数=19，支架数=32）。对所有支架节段进行OCT检查后应用LightLab系统配备的软件进行图像分析。以64、168和366μm为分界点将增生内膜厚度进行区问划分，评价3种DES的内膜覆盖厚度以及内膜增生的匀称性。结果3组的内膜完全覆盖率差异无统计学意义（P〉0．05）。内膜增生厚度Cypher支架组为（178．7±11．9）μm、Endeavor支架组为（228．7±17．1）μm、Firebird支架组为（170．3±13．3）μm，任意2组间比较差异均有统计学意义（均P〈0．05）。Cypher支架组内膜增生均匀性优于Firebird支架组，Firebird支架组优于Endeavor支架组。结论不同类型DES置入后的内膜覆盖情况存在荠异。OCT可以评价不同类到DES问内障增毕均匀忡的善导．
Objective To assess the neointimal coverage after the implantation of various drug eluting stents （ DES ） by optical coherence tomography （ OCT ）. Methods The study comprised of 62 patients implanted DES for （ 15.3 ± 5.7 ） months. Patients were divided into three groups according to the type of implanted stent ： Cypher group （ patient = 26, stent = 57 ）, Endeavor group （ patient = 17, stent = 23 ） and Firebird group （patient = 19, stent = 32）. OCT images of the stent were analyzed by software equipped by Light Lab system. Intimal thickness of 64 pμm, 168 μm and 366 μm represents 10% , 25% and 50% lumen area loss, respectively. Neointimal coverage was thin with intimal thickness ≤64 μm, satisfactory with intimal thickness between 65 μm and 366 p,m and hyperplaisa and restenosis with intimal thickness 〉 366 μm. Results The percent of complete neointimal coverage was similar among groups （ P 〉 0.05 ）. The thickness of neointimal coverage in Cypher and Endeavor and Firebird group was （ 178.7 ± 11.9 ） μm, （228.7 ± 17. 1 ） μm and （ 170. 3 ± 13.3 ） μm, respectively（ all P 〈 0.05 ）. The symmetry of Cypher stent was better than Firebird stent, and the symmetry of Firebird stent was better than Endeavoe stent. Conclusion There was significant difference on neointimal coverage after various types of DES implantation, and OCT can be used to evaluate the symmetry of neointimal coverage post implantation of various DES.
出处
《中华心血管病杂志》
CAS
CSCD
北大核心
2011年第3期204-207,共4页
Chinese Journal of Cardiology
