摘要
目的:探讨消痈溃得康颗粒对胃溃疡活动期患者血清IL-6及IL-8的影响,反证"毒热"为胃溃疡活动期的病因,IL-6及IL-8等细胞因子为"毒热"病因要素的生物学基础。方法;选取胃溃疡活动期符合中医胃毒热证患者300例,采用随机对照双盲双模拟实验研究方法,实验组口服消痈溃得康颗粒加溃疡胶囊模拟剂,对照组口服溃疡胶囊加消痈溃得康颗粒模拟剂,6周后观察中医症状积分变化;采用ELASA法测定实验组、对照组各22例血清IL-6及IL-8的变化,进行统计分析。结果:治疗组脱落8例,对照组脱落6例。中医证候积分(PPS)实验组疗前(10.606±3.26)分,与疗后(1.331±1.54)分比较,P<0.01,有显著统计学差异;对照组疗前(10.313±3.32)分,与疗后(4.056±2.35)分比较,P<0.01,有显著统计学差异;两组疗后比较,P<0.01,有显著统计学差异。实验组疗后IL-6(1.04±0.10)ng/L、IL-8(86.44±9.58)ng/L与疗前(1.49±0.13)ng/L、(135.00±17.26)ng/L比较,P<0.01,有显著统计学差异;对照组疗后IL-6(1.40±0.11)ng/L、IL-8(120.94±11.26)ng/L与疗前(1.51±0.10)ng/L、(136.13±18.22)ng/L比较,P<0.01,有显著统计学差异;两组疗后IL-6及IL-8比较,P<0.01,有显著统计学差异;结论:清热解毒、消痈生肌之消痈溃得康颗粒可以明显降低胃溃疡活动期患者血清IL-6及IL-8的水平,改善中医症状,从而达到治疗溃疡的目的,且疗效优于对照组,以效测证,反证"毒热"确为胃溃疡活动期的病因,IL-6及IL-8等细胞因子为"毒热"病因要素的生物学基础。
Objective：Disprooving the＂poison - heat＂ was the etiopatho - genisis of gastric ulcer in active stage and eytokine as IL - 6/IL - 8 were biological substructure of ＂poison - heat＂ through aprroching the action of Xiaoyongkuidekang Granule acted on IL-6/IL -8 in serum of patients with gastric ulcer in active stage. Methods ：300 patient with gastric ulcer in active stage were selected with features of gastric poison - heat syndrome in TCM and devided into experiment and control group with double - blind /simulation test randomly. Patient in experiment group were treated with Xiaoyongkuidekang Granule and Kuiyang simulated capsule;Patient in control group were treated with Kuiyang capsule and Xiaoyongkuidekang simulated Granule. IL -6/IL -8 in serum tested by elisa method and symptoms integral of TCM collected in 6 weeks were analyzed statistically. Results ：There were 8 cases lost in experimental group and 6 eases lost in control group. There were significant statistical difference of symptoms integral of TCM collected after treatment（ 1. 667±2.11 ） compared with integral collected before treatment （ 10. 633±3.37 ） which got a P 〈 0.01 in experiment group. There were significant statistical difference of symptoms integral of TCM collected after treatment （4.500±2.39）compared with integral collected before treatment（ 10.700±3.28） which got a P 〈 0.01 in control group. There were significant statistical difference of symptoms integral of TCM collect after treatment between groups which got a P 〈 0.01. There were significant statistical difference of serum IL - 6 （ 1.04±0.10 ） ng/L and IL - 8 （ 86.44 ±9.58 ） ng/L（ after treatment ） compared with IL - 6 （ 1.49±0.13 ） ng/L and IL - 8 （ 135.00±17.26 ） ng/L （ before treatment） which got a P 〈 0.01 in experiment group. There were significant statistical difference of IL - 6 （ 1.40±0.11 ） ng/L and IL - 8 （ 120.94±11.26 ） ng/L （ after treatment） compared with IL - 6 （ 1.51±0.10） ng/L and IL - 8 （ 136.13±18.22 ） ng/L（ before treatment） which got a P 〈 0.01 in control group. There were significant statistical difference of IL - 6/IL - 8 （ after treatment） between groups which got a P 〈 0.01. Conclusion：Xiaoyongkuidekang Granule depressed the level of serum IL -6/IL -8 and improved symptoms of TCM of gastric ulcer,got a better effect in the treatment of gastric ulcer in active stage than control group which disproved the ＂ poison - heat＂ was the etiopatho - genisis of gastric ulcer in active stage and cytokine as IL - 6/IL - 8 were biological substructure of＂ poison - heat＂.
出处
《辽宁中医杂志》
CAS
北大核心
2011年第5期815-817,共3页
Liaoning Journal of Traditional Chinese Medicine
基金
国家重点基础研究发展计划("973"计划)资助(2006CB504809)
