摘要
以CLSI提出的两种细菌药敏试验方法(纸片扩散法和肉汤稀释法)和对"breakpoint"标准的拟定为例,基于菌群生长动力学和临床对抗菌药物选择的需要,分析现行药敏试验存在的问题,并就病原菌的生态学、breakpoint制定、药敏试验方法的规范和抗药性网络建设等方面提出建议。
Taking the disk diffusion method and broth dilution method and their ＂breakpoint＂ standard proposed by the Clinical and Laboratory Standards Institute（CLSI） as an example,problems of these classic antimicrobial susceptibility tests were analyzed based on bacterial growth kinetics and the clinical choice of antimicrobial drugs.Then recommendations were made in the ecology of pathogens,breakpoint division,methodological criteria for antimicrobial susceptibility tests,and the antimicrobial resistance monitoring net.
出处
《山东大学学报（医学版）》
CAS
北大核心
2011年第3期124-132,共9页
Journal of Shandong University:Health Sciences
基金
国家自然科学基金资助课题(30770044)
山东省中青年科学家科研奖励基金资助课题(2006BS02008)
山东省自然科学基金资助课题(ZR2010HQ047、Y2007D35)
关键词
药敏试验
抗药性
耐药性
BREAKPOINT
Antimicrobial susceptibility testing
Antimicrobial resistance
Antimicrobial tolerance
Breakpoint
