摘要
目的对胰岛素泵与传统胰岛素皮下注射治疗初诊2型糖尿病的临床效果和胰岛β细胞功能改善情况进行对比。方法对67例2型糖尿病患者随机分为胰岛素泵持续皮下输注胰岛素治疗组(CSII组)35例和多次皮下输注胰岛素治疗组(MSII组)32例,观察两组的空腹血糖(FPG)、餐后2h血糖(2hPG)、每日胰岛素用量、血糖达标时间及低血糖发生情况。结果两组治疗前后血糖均明显下降(P<0.01),但两组间比较血糖差异无显著性(P>0.05),CSII组血糖达标时间明显短于MSII组(P<0.05);低血糖发生次数明显少于MSII组(P<0.05)。结论胰岛素泵持续皮下输注治疗更符合生理状态下的胰岛素分泌,能更快、更有效地降低血糖,减少低血糖的发生,同时促进了胰岛β细胞功能的恢复,对初诊2型糖尿病治疗有长期意义。
Objective To compare the clinical effect of insulin pump and conventional insulin therapy in newly diagnosed type 2 diabetes,subcutaneous injection and improvement of islet β cell function were compared.Methods Totally 67 patients with type 2 diabetes were randomly assigned to continuous subcutaneous insulin infusion pump insulin therapy（CSII group） 35 cases and multiple subcutaneous insulin infusion treatment group（MSII group） 32 cases,were observed in fasting plasma glucose（FPG）,postprandial 2h plasma glucose（2hPG）,daily insulin dosage,blood glucose time and the incidence of low blood sugar.Results Both before and after treatment were significantly lower blood glucose（P0.01）,but blood glucose difference between the two groups was not significant（P0.05）,CSII group blood glucose was significantly shorter in the MSII group（P0.05）,frequency of hypoglycemia was significantly less than the MSII group（P0.05）.Conclusions The continuous subcutaneous infusion insulin pump more insulin secretion under physiological conditions,faster and more effectively reduce blood sugar,reduce the incidence of low blood sugar,while promoting the recovery of islet β cell function,the treatment of newly diagnosed type 2 diabetes has long-term significance.
出处
《医药论坛杂志》
2011年第5期109-110,115,共3页
Journal of Medical Forum
关键词
2型糖尿病
胰岛素泵
强化治疗
Type 2 diabetes mellitus
Insulin pump
Intensive Treatment
