摘要
目的探讨槟榔碱对2型糖尿病大鼠凝血功能和血液流变学的影响。方法 Sprague-Dawley(S-D)大鼠高糖高脂饮食喂养4周后,腹腔注射链脲佐菌素(30 mg/kg)建立2型糖尿病模型。模型建成后将大鼠随机分为6组:正常对照组、模型组、槟榔碱治疗组(1 mg/kg,5 mg/kg和20 mg/kg)。槟榔碱处理12周后,心脏采血测定各组大鼠空腹血糖水平、凝血功能指标、血浆纤维蛋白原含量和血液流变学指标。结果与正常对照组相比较,模型组大鼠的空腹血糖水平显著性升高,凝血酶原时间、凝血酶时间、活化部分凝血激酶时间显著性降低和纤维蛋白原含量显著性升高,全血黏度、血沉、红细胞压积和红细胞聚集指数显著性增加,而红细胞变形指数显著性降低,而5mg/kg和20 mg/kg槟榔碱显著性降低大鼠的空腹血糖水平,明显改善凝血功能指标和血液流变学指标的异常变化。结论槟榔碱能改善2型糖尿病大鼠凝血功能和血液流变学的异常。
Aim To investigate the effects of arecoline on blood coagulation and hemorrheology in type 2 diabetic rats. Methods Sprague-Dawley（S-D） rats were fed high-fat and high-fructose diet for four weeks and then were injected streptozotocin（30 mg/kg） to induce the type 2 diabetes.Once the type 2 diabetes models were set successfully,type 2 diabetic rats were randomized into five groups： normal control group,diabetes models group,arecoline groups（1 mg/kg,5 mg/kg and 20 mg/kg）.The rats were treated with arecoline through intragastric administration for twelve weeks.At the end of the twelfth week,the level of fasting blood glucose,the level of blood plasma fibrinogen（Fbg） and the coagulation indexes including thrombin time（TT）,prothrombin time（PT） and activated partial thromboplastin time（APTT） were detected.The hemorrheology indexes inculding blood viscosity,erythrocyte sedimentation rate,volume of packed red cells,erythrocyte aggregation index and erythrocyte deformity index were also detected. Results Compared with the normal control group,the level of fasting blood glucose was significantly increased,TT,PT and APTT were significantly decreased and the level of blood plasma Fbg was significantly increased in the diabetes models group.Compared with the normal control group,blood viscosity,erythrocyte sedimentation rate,volume of packed red cells and erythrocyte aggregation index were significantly increased,but erythrocyte deformity index was significantly decreased in the diabetes models group.Compared with the diabetes model group,the level of fasting blood glucose was significantly decreased and the indexes of coagulation and hemorrheology were improved in arecoline（5 mg/kg and 20 mg/kg） group.Conclusion Arecoline improves the blood coagulation and hemorrheology in type 2 diabetic rats.
出处
《中国动脉硬化杂志》
CAS
CSCD
北大核心
2011年第4期319-322,共4页
Chinese Journal of Arteriosclerosis
