摘要
目的探讨超声引导脐静脉穿刺术在孕中晚期产前诊断中的安全性及应用价值。方法对875例孕周为18~33＋4的孕中晚期孕妇因各种原因行超声引导脐静脉穿刺术,并对所抽取的脐静脉血进行核型分析。结果超声引导脐静脉穿刺成功率为99.5%;胎盘或脐带一过性渗血发生率22.5%;胎儿短暂心动过缓发生率4.0%;胎儿丢失发生率0.5%。染色体核型分析发现核型异常65例,异常率为7.4%,其中数目异常41例;结构异常24例。另发现重型地中海贫血8例,巨细胞病毒感染2例。异常诊断结果总检出率为8.6%。结论超声引导下脐静脉穿刺术具有很高的成功率和安全性,弥补了孕中晚期产前诊断方法的空缺,并能从多方面进行病因学诊断。
Objective：To explore the application value and safety of ultrasound guided umbilical blood sampling in the prenatal diagnosis of second and third trimester.Methods： 875 pregnant women（pregnant time form 18~33＋4 weeks） with indication of various reasons underwent cordocentesis guided by B type ultrasound.Then chromosomal karyotype analysis of cord blood was carried out.Result： The success rate of this technology was 99.5%.The incidence rates of capillary hemorrhage of placenta or umbilical cord and fetus bradycardia and dead fetuses were 22.5%,4.0% and 0.5% respectively.65 fetuses were found chromosome abnormalities.The rate was 7.4%,including 41 fetuses of numerical abnormality and 24 fetuses of structural abnormality.In addition,8 examples of thalassemia major were found and 2 examples of cytomegalovirus infection as well.Such,the total detection rate of abnormality diagnosis reached 8.6%.Conclusion： Ultrasound guided umbilical blood sampling has high success rate and security.It can not only make up the weakness of diagnosis methods of second and third trimester,but be applied to aetiological diagnosis in many ways.
出处
《中国优生与遗传杂志》
2011年第6期54-55,共2页
Chinese Journal of Birth Health & Heredity
关键词
脐静脉穿刺
超声引导
产前诊断
孕中晚期
Umbilical blood sampling
Ultrasound guided
Prenatal diagnosis
Second and third trimester
