摘要
目的:研究宫颈癌调强放疗计划设计中膀胱壁与膀胱受照剂量的差别,从而在计划设计中正确设置和评价膀胱的限制剂量。方法:随机选取19例宫颈癌病例,为其设计调强计划。为了便于比较,分别给19例患者设计第一程全盆照射计划,处方剂量50 Gy/25次,利用DVH图分别评价膀胱和膀胱壁的受量。结果:调强计划中膀胱、膀胱壁的最小剂量、最大剂量差异均无统计学意义。膀胱平均剂量、D70、D50、D40和D30分别为38.45、30.07、38.68、43.90和47.54 Gy,膀胱壁平均剂量、D70、D50、D40和D30分别为40.97、32.80、45.83、49.16和50.24 Gy。用膀胱所受剂量评价膀胱壁剂量,膀胱壁平均剂量、D70、D50、D40和D30分别被低估6.55%、9.08%、18.49%、11.98%和5.68%。结论:在宫颈癌调强计划设计中,简单的用整个膀胱受量评价膀胱壁受量,将会低估膀胱壁的真正受量,从而加大膀胱并发症的概率,对膀胱造成不必要的损伤。
OBJECTIVE： To study the difference of dose between bladder wall and bladder in IMRT plan, so as to set and evaluate the dose-limiting of bladder correctly. METHODS： Nine teen cases of cervical cancer were chosen randomly to be design IMRT plan. In order to be easy for comparison, the whole pelvic radiation plan were made for 19 cases, the prescribe dose was 50 Gy/25 f and DVH were made to evaluate the dose of bladder wall and bladder. RESULTES.. There was no obvious difference in the most and least dose of bladder wall and bladder in IMRT plan. The mean dose, D70, D50, D40 and D30 of bladder was 38. 45, 30. 07, 38. 68, 43. 90 and 47. 54 Oy reseparately. Tbe mean dose, D70, D50, D40 and D30 of bladder wall was 40.97, 32.80, 45.83, 49.16 and 50.24 Gy. It meant that if the dose of bladder wall were evaluated by the dose of bladder, the mean dose, D70, D50, D40, and D30 of bladder wall would be under estimated 6.55%, 9.08%, 18.49%, 11.98% and 5.68% reseparately. CONCLUSION： The dose of bladder wall will be underestimated if it have been evaluated by the dose of bladder in IM RT plan, which will lead to the increase of complication of blad der and unnecessary injury as well.
出处
《中华肿瘤防治杂志》
CAS
2011年第6期463-465,共3页
Chinese Journal of Cancer Prevention and Treatment
