摘要
目的 :对部分国家级核心临床医学期刊近年来发表的病因学研究论文的方法学进行评价。方法 :华西医科大学地区临床流行病学资源与培训中心组织临床流行病学教师对上述 6种中华系列临床医学杂志在过去三年中 ( 1994 7～ 1997 6 )发表的部分病因学研究论文用统一的指标进行评价。结果 :共收集论文 6 1篇 ,其中队列研究 14篇 ,病例对照研究 15篇 ,断面研究 3 2篇。队列研究 14篇中仅有 5篇考虑了混杂因素 ,仅有 6篇应用了OR或RR等测量因果联系强度的指标。病例对照研究 15篇中 14篇用比值比OR表示因果联系的强度 ,10篇采用了统计学方法处理混杂因素。断面研究 3 2篇中用RR或OR表示因果关系者 8个 ,余均采用率的比较、t检验及相关关系等表示变量之间的关系 ,有 14个研究样本偏小。结论 :约半数病因学研究论文存在较严重的方法学缺陷 ,影响研究结果的真实性。为了提高病因学研究质量 。
Objectives:For a critical appraisal to the methodology of the causation studies.Methods:The Regional Clinical Epidemiology Resources and Training Center organized some of its faculty members to evaluate the methodology of causation studies published from July 1994 to June 1997 in 6 Zhonghua medical journals using same standard.Results:Altogether 61 articles were collected,in which 14 were cohort studies,15 case-control studies and 32 cross-sectional studies.In 14 cohort studies,confounding was considered in just 5 studies,and OR,RR the causation measurement variables were only used in 6 studies.Whereas in 15 case-control studies OR was employed in 14 articles,confounding was analyzed in 10 articles.Within 32 cross-sectional studies,RR of OR was used in only 8 reports.The others used rates comparisons,t test and correlation etc.to express the relations between variables.14 studies had very small samples.Conclusion:In 61 causation studies,about half of them had severe methodological deficiency,and validity of the studies was affected.To improve quality of the causation studies,clinical epidemiology should be integrated into the content of continuing education for clinicians.
出处
《华西医学》
CAS
1999年第3期257-259,共3页
West China Medical Journal
关键词
病因学
队列研究
病例对照研究
临床流行病学
Causation
Cohort study
Case-control study
Cross-sectional study
Bias
