摘要
目的探讨IgA肾病患儿肾组织中血管内皮细胞生长因子(VEGF)及其受体VEGF2R2(flk21)表达,并将其表达水平与临床病理改变进行相关性分析。方法免疫组织化学SP法。结果肾小球内VEGF和flk21在中度病变组肾小球内表达最多,重度病变组表达最少,两组相比较,差异具有统计学意义(P<0.05)。轻、中度病变组肾小球内VEGF表达与尿蛋白含量呈正相关(P<0.05)。肾小球VEGF表达与肾小球微血管密度呈正相关(P<0.05),重度病变组肾小球微血管密度明显减少(P<0.05)。结论本研究表明VEGF在小儿IgA肾病的发病进展过程中起着重要作用,其作用机制有细胞外基质合成增多、内皮细胞通透性增强、血管生成障碍等。
Objective To explore the children in the kidney tissues IgA nephropathy vascular endothelial growth factor（VEGF） and its receptor VEGF2R2（flk21） expressing,and its expression level and the relevant analysis of clinical pathological changes.Methods Immunohistochemical SP method.Results In flk21 glomerular inside VEGF and moderate lesions group most,severe glomerular expressed in the least,two lesions group expression compared,differences of a statistically significant（P0.05）.Light,medium lesions group within the glomerulus with urinary protein content express VEGF positively related（P0.05）.Glomerular VEGF expression and positively correlated glomerular capillary density（P0.05）,adanced lesions glomerular microvessel density significantly reduce group（P0.05）.Conclusion This study shows that VEGF the onset of pediatric IgA nephropathy in progress plays an important role in the process,and its mechanism have extracellular matrix synthesis increase,endothelial cells permeability increase,angiogenesis,obstacles and so on.
出处
《中国医药指南》
2011年第16期49-50,共2页
Guide of China Medicine
