摘要
目的:探讨胃癌患者血清血脂、脂蛋白及癌胚抗原(CEA)、糖链抗原(CA199)水平的变化及临床意义。方法:选择胃癌患者158例,未手术而直接化疗者62例(TNM分期M1期,38例、M0期24例),手术后辅助化疗者96例(术后病理分期Ⅰ期15例、Ⅱ期25例、Ⅲ期33例、Ⅳ期23例);正常对照100例;良性疾病组(胃炎和胃溃疡)80例。测定其血清甘油三酯(TG)、胆固醇(TC)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、CEA及CA199水平。结果:胃癌组血清TG、CEA、CA199较其他2组升高(P<0.05),而TC、HDL、LDL则下降(P<0.05)。胃癌患者术后血清TC、LDL较术前增高(t=20.315、24.557,P<0.001)。胃癌患者TNM分期或病理分期越高,TC、HDL、LDL水平越低,CEA、CA199水平越高(P<0.05)。上述指标血清水平与近期疗效无关(P>0.05)。结论:血脂、脂蛋白水平可辅助胃癌诊断和临床病理分期的判断。
Aim：To detect the serum levels of blood-lipid,lipoprotein,carcinoembryonic antigen （CEA） and carbohydrate antigen（CA199） of gastric carcinoma patients.Methods：A total of 158 cases of gastric cancer,including 62 cases treated only by chemotherapy directly（38 metastasis cases and 24 no metastasis cases） and 96 cases treated operation and adjuvant chemotherapy（15 cases in pathologic stageⅠ,25 cases in stage Ⅱ,33 cases in stage Ⅲ ,23 cases in stage Ⅳ）,were to detect the serum levels of TG,TC,HDL,LDL,CEA,and CA199.100 normal casesand 80 cases of benign disease（gastritis and gastric ulcer） were the controls.Results：The levels of TG,CEA,CA199 in gastric cancer group were higher than those in the other two groups （P0.05）,while the levels of TC,HDL,LDLwere lower （P0.05）.The levels of TC,LDL of gastric cancer group after operation were higher than those before operation （t=20.315,24.557,P0.001）.Differences in the levels of TC,HDL,LDL,CEA,CA199 among different pathologic stages were significant in gastric cancer group（P0.05）.The levels of the indexes mentioned above were not related with the therapy（P0.05）.Conclusion：Blood-lipid and lipoprotein could be helpful for the diagnosis and adjudging the stages of clinical pathology of gastric cancer.
出处
《郑州大学学报（医学版）》
CAS
北大核心
2011年第3期432-435,共4页
Journal of Zhengzhou University(Medical Sciences)
关键词
胃癌
血脂
脂蛋白
CEA
CA199
gastric carcinoma
blood lipid
lipoprotein
CEA
CA199
