摘要
【目的】探讨运动训练对老年慢性心力衰竭（CHF）患者心功能和血清胱抑素C（CysC）浓度的影响。方法 172例心功能Ⅱ～Ⅲ级老年CHF患者随机分为训练组（n=36）和对照组（n=36），入选后即行6分钟步行试验（6MwT）、检测CysC浓度、超声多普勒检测心功能。对照组常规给予抗心衰药物治疗，在此基础上训练组每天行2次6MWT运动强度的步行训练。8周后复查6MWT、血清CysC浓度、行超声多普勒检测心功能。【结果】两组患者6MWT距离心功能Ⅲ级患者均显著短于Ⅱ级患者（P〈O．05），CysC水平Ⅲ级患者均显著高于Ⅱ患者（P〈O．05）。治疗8周后两组患者血清CysC浓度均有显著下降（P〈0．05），6MWT距离明显增加（P〈0．01，P〈O．05），心功能客观指标明显提高（P〈0．05），但训练组改善程度显著优于对照组（P〈0．01）。【结论】运动训练可以显著提高老年CHF患者的运动能力并降低血清CysC浓度，改善心功能。
[Objective]To explore the effect of physical training on cardiac function and serum cystatin C （CysC） level in elderly patients with chronic heart failure（CHF）. [Methods] Totally 72 elderly NYHA lI - Ⅲ patients were randomly divided into the training group（ n = 36） and the control group（ n = 36）. After patients were selected, the 6-minute walking test（6MWT） was performed. Serum level of CysC was determined and the cardiac function was detected by ultrasound Doppler cardiogram. The control group was treated with anti- CHF drugs. The training group was additionally given walking exercise with 6MWT exercise intensity twice a day. After 8 weeks, the 6MWT distance, serum levels of CysC and cardiac function were reexamined. [Results] The 6MWT distance of the NYHA]II patients was significantly shorter than that of the NYHA 1I patients（ P 〈0.05）. Serum CysC level of the NYHA Ⅲ patients was significantly higher than that of NYHA Ⅱ patients（ P 〈0.05）. After treatment for 8 weeks, serum CysC level in both groups significantly reduced （ P 〈0.05）, and the 6MWT distance and other indicators of cardiac function were significantly improved（ P 〈0.01, P 〈0.05）. The improvement in the training group was better than that in the control group（ P 〈 0.01）. [Conclusion] Physical training can significantly improve motor ability, and reduce the serum level of CysC, and improve cardiac function of elderly patients with CHF.
出处
《医学临床研究》
CAS
2011年第5期894-896,共3页
Journal of Clinical Research
关键词
心力衰竭
充血性
慢性病
运动
heart failure,congestive
chronic diseases
exercise
