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肿瘤坏死因子-β遗传变异与食管癌发病风险的关系 被引量:2

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摘要 食管癌是危害人类生命和健康的严重疾病之一,研究表归,饮食因素和环境因素是我国食管鳞癌的最主要危险因簧,遗传变异是肿瘤个体易感性的重要原因。肿瘤坏死目子(TNF)在多种恶性肿瘤的发生发展过程中发挥着重要向作用。有报道显示,位于TNF-β基因第一内含F+252位的G〉A变异可导致该基因转录活性的增加。力能性刑TNF-β+252G〉A遗传变异可能是食管癌发生的重要遗传易感因素。为验证该假设,
出处 《中华预防医学杂志》 CAS CSCD 北大核心 2011年第7期661-662,共2页 Chinese Journal of Preventive Medicine
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同被引文献38

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