摘要
目的探讨治疗尿毒症难治性高血压的有效方法。方法将120例CRF伴难治性高血压患者随机分为两组。A组应用每周3次标准血液透析治疗;B组行每周1次常规标准血液透析治疗和每周2次血液透析滤过治疗。比较两组患者治疗前及治疗后8周甲状旁腺素、血浆肾素、血管紧张素Ⅱ、平均动脉压的变化。结果 B组平均动脉压降低较A组更加显著,与A组比有显著性差异（P〈0.01）。B组治疗后血浆、肾素、血管紧张素Ⅱ以及甲状旁腺素下降明显,与治疗前比较有显著性差异（P〈0.05）。结论血液透析滤过能有效地清除血浆RA、AngⅡ、甲状旁腺素等中分子毒素,治疗难治性高血压效果优于血液透析,值得临床推广。
Objective To investigate the treatment of refractory hypertension in uremia effective way.Methods 120 patients with refractory hypertension in patients with CRF were divided into 2 groups.A Group standards applied 3 times per week hemodialysis treatment;B group 1 week,conventional standard hemodialysis treatment and 2 times a week hemodiafiltration treatment.Patients were compared before and 8 weeks after treatment,parathyroid hormone,plasma renin,angiotensin Ⅱ,mean arterial blood pressure changes.Results B The mean arterial blood pressure is more significant than the A group,compared with the A group there was significant difference（P0.01）.B After treatment,plasma Renin,angiotensin Ⅱ and parathyroid hormone decreased significantly,compared with before treatment there was significant difference（P0.05）.Conclusion Hemodialysis can effectively remove the plasma RA,AngⅡ,parathyroid hormone and other middle molecular toxins,better than the treatment of refractory hypertension in hemodialysis and is worthy of promotion.
作者
张雷明
ZHANG Lei-ming（First Affiliated Hospital of Nanyang specific blood purification Medical Branch,Nanyang 473058,China）
出处
《医学信息》
2011年第13期4231-4232,共2页
Journal of Medical Information
