摘要
本文概述了几种常见难愈创面的发生原因及发病机制。难愈创面常见有静脉性溃疡、压迫性溃疡、失神经性溃疡、糖尿病足溃疡,大面积深度烧伤、电击伤,大剂量放射性损伤以及高原、海域等环境中发生的创伤创面等。多种难愈创面常因致伤因素、发生部位解剖学特点、自身或受外界因素影响而引起全身病变,一旦局部受创,其炎细胞、组织修复细胞、细胞外基质和细胞因子等的网络调控失调,细胞增殖、迁移、血管生成、上皮再生等系列创面修复机制发生障碍,致使创面难以愈合。
Etiologies and pathogenesis of several kinds of delayed wound healing were summarized in this paper.Delayed wound healings are mainly developed as venous ulcer,pressure ulcer,denervated ulcer,diabetic ulcer,wounds in large-area deep burn and electric burns,radiation wound following by severe high-dose irradiation,wound occurred in high altitude and sea area etc.The severity of trauma,anatomic characteristics of injured part,harmful environmental as well as the whole body conditions of patients are important factors in the occurrence of delayed wound healing.While the interaction among inflammatory cells（especially the neutrophils and macrophages）,tissue repair cells（fibroblast,vascular endothelial cells and epithelial cells）,extracellular matrixes and cytokines became disordered,a series mechanisms of proliferation,apoptosis,and migration of cells,expression of matrixes and cytokines became impaired,resulting in delayed wound healing.
出处
《创伤外科杂志》
2011年第4期368-370,共3页
Journal of Traumatic Surgery
关键词
创面
溃疡
病因
wound
ulcer
cause of disease
