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泛素蛋白连接酶Itch生物活性及其免疫调节作用 被引量：4

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摘要 泛素-蛋白酶体通路是选择性降解蛋白质的重要途径,在细胞分裂调节、DNA修复及肿瘤细胞消除等方面具有重要作用。E3泛素连接酶能够特异性识别并结合底物蛋白,是泛素-蛋白酶体通路中靶蛋白降解的关键调节分子。Itch是近期发现的一种高度保守的HECT家族E3泛素连接酶,在免疫调节、细胞凋亡等多种生物过程中发挥重要调节功能。本文对泛素连接酶Itch生物活性的研究进展作一综述。
作者 唐冰 包娜仁 王俊科
机构地区 中国医科大学附属第一医院麻醉科
出处 《现代免疫学》 CAS CSCD 北大核心 2011年第4期344-347,共4页 Current Immunology
关键词 ITCH 泛素 连接酶 免疫调节 细胞凋亡
分类号 R392 [医药卫生—免疫学]
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参考文献20

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同被引文献34

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引证文献4

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现代免疫学
2011年 第4期

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