摘要
目的:观察复方炔诺酮治疗功能失调性子宫出血的临床疗效。方法:将符合病例入选标准的120例功能失调性子宫出血患者随机分为2组,每组60例。治疗组治以复方炔诺酮,对照组采用炔雌醇环丙孕酮片治疗。两组均以连续用药22天为1个疗程,持续治疗6个疗程后观察疗效。结果:显效率治疗组为75.00%,对照组为55.00%,差异有统计学意义(P<0.05);总有效率治疗组为95.00%,对照组为73.33%,差异有统计学意义(P<0.05)。E2、P、FSH、LH水平两组治疗前后组内相比差异有统计学意义(P<0.05),治疗后两组组间差异亦有统计学意义(P<0.05)。月经周期、血红蛋白、子宫内膜厚度两组治疗前后组内相比差异有统计学意义(P<0.05),治疗后两组组间差异亦有统计学意义(P<0.05)。不良反应发生率治疗组为8.33%,对照组为10.00%,差异无统计学意义(P>0.05)。结论:复方炔诺酮治疗功能性子宫出血临床疗效显著,可明显改善E2、P、FSH、LH、月经周期、血红蛋白、子宫内膜厚度等各项指标,且不良反应小。
Objective：To observe the clinical efficacy of compound norethindrone in the treatment of dysfunctional uterine bleeding.Methods：120 patients with dysfunctional uterine bleeding were randomly divided into two groups.Treatment group（60 cases） were treated with compound norethisterone,the control group（60 cases） were treated with ethinyl estradiol cyproterone tablets.Continuous medication 22 days were a course of treatment for the two groups,continued treatment effects were observed after 6 courses.Results：The efficiency of the treatment group and control group was 75.00% and 55.00% respectively,the difference between the two groups was statistically significant（P0.05）.Total effective rate in treatment group and control group was 95.00% and 73.33% respectively,the difference between the two groups was statistically significant（P0.05）.The levels of E2,P,FSH,LH and other test indicators of two groups before treatment had statistically significant difference compared with those after treatment（P0.05）.The difference was also statistically significant between the two groups after treatment（P0.05）.Menstrual cycle,hemoglobin,changes in endometrial thickness for the two groups had statistically significant difference before and after treatment（P0.05）.The difference was also statistically significant between the two groups after treatment（P0.05）.The incidence of adverse reactions was 8.33% and 10.00% in treatment group and control group respectively,the difference was not significant（P0.05）.Conclusion：The clinical effect of the compound norethisterone for the treatment of dysfunctional uterine bleeding is significant,it can improve E2,P,FSH,LH,menstrual cycle,hemoglobin,endometrial thickness,and has small the side effects.
出处
《中国妇幼保健》
CAS
北大核心
2011年第20期3062-3064,共3页
Maternal and Child Health Care of China
关键词
功能失调性子宫出血
复方炔诺酮
炔雌醇环丙孕酮
Dysfunctional uterine bleeding
Compound norethisterone
Ethinyl estradiol cyproterone
