摘要
目的探讨恶性黑色素瘤(MM)根治术后自体树突状细胞(DC)疫苗辅助治疗的临床疗效。方法 42例Ⅱ、Ⅲ期肢体MM术后患者分为两组,30例患者接受白细胞介素2(IL-2)/干扰素-α2b(IFN-α2b)常规免疫治疗(常规组),12例患者常规治疗同时联合DC疫苗(疫苗组)。观察DC疫苗的临床安全性和对患者免疫功能的影响。结果与常规组比较,疫苗组治疗后外周血CD3+、CD3+CD4+、CD4+/CD8+比值、自然杀伤(NK)细胞比率明显升高(P<0.05),治疗中无严重不良反应发生。随访结果显示,DC疫苗治疗能够显著延长根治手术后MM患者的无复发生存期。结论联合DC疫苗的免疫治疗能够提高MM根治术后患者的免疫功能,降低其复发转移,可作为MM患者安全有效的辅助治疗手段。
Objective To investigate the outcomes of treating malignant melanoma（MM） with autologous dendritic cells（DC） vaccine after operation.Methods Fourty-two postoperative MM cases were devided into groups of A（30 cases,treated with conventional therapy of IL-2/IFNα-2b） and B（12 cases,treated with additional autologous DC vaccine）.The patients were followed up and the immune function was observed.Results Compared to group A,the levels of CD3＋,CD3＋CD4＋T cells,the ratio of CD4＋/CD8＋,natural killer cells in group B were significantly increased（P0.05）.The follow-up displayed that the DC vaccine prolonged the no-relapse survival time without severe side effects.Conlusions The DC vaccine could impove the immune function and reduce recurrence and may be taken as an adjuvant threrapy in the patients with MM after radical operation.
出处
《江苏医药》
CAS
CSCD
北大核心
2011年第14期1669-1671,共3页
Jiangsu Medical Journal
