摘要
目的:研究卡马西平(CBZ)在癫痫患儿中的群体药动学。方法:回顾性收集我院119例服用CBZ的门诊癫痫患儿的稳态血药浓度(n=122)。用非线性混合效应模型(NONMEM)法进行数据分析,定量考察年龄、性别、体重、日剂量和合用其他抗癫痫药对CBZ清除率的影响。采用一房室开放模型和一级吸收和消除的药动学模型,按照固定吸收速率常数文献值,最终求算CBZ的清除率。结果:最终拟合群体药动学模型为:CL=0.593·(体重/28.5)0.63·日剂量0.569。性别、合用丙戊酸钠不影响CBZ的清除率。结论:用NONMEM法估算CBZ的清除率和推荐剂量,可为临床制订个体化给药方案、提高疗效、降低药物的毒副作用提供依据。
OBJECTIVE：To investigate the population pharmacokinetics of carbamazepine （CBZ） in epileptic children.METHODS：Steady state serum concentrations data （n=122） were collected from 119 patients of our hospital during their routine clinical care.The effects of age,gender,body weight,daily dose and combined with other antiepileptic drugs on the clearance rate of CBZ were investigated by using Nonlinear mixed effect model （NONMEM）,and the clearance rate of CBZ was calculated using a one-compartment model and first-order absorption and elimination pharmacokinetic model according to absorption rate constant.RESULTS：The final fitted pharmacokinetic model was：CL=0.593·（WT/28.5）0.63·（daily dose）0.569.Gender and combined with VPA didn＇t alter the CBZ clearance rate.CONCLUSION：NONMEM used to calculate clearance rate and recommended dose of CBZ can provide basis for the formulation of individual dosage regimen,efficacy improvement and toxicity effect reduction.
出处
《中国药房》
CAS
CSCD
北大核心
2011年第30期2819-2821,共3页
China Pharmacy
基金
2010年深圳市科技计划项目(201003145)
关键词
儿童
卡马西平
群体药动学
非线性混合效应模型
Children
Carbamazepine
Population pharmacokinetics
Nonlinear mixed effect model
