摘要
目的 评估红细胞体积分布宽度（RDW）与2型糖尿病（T2DM）患者颈动脉内中膜厚度（IMT）的关系.方法 将225例T2DM患者按照IMT是否正常进行分为2组,IMT正常组45例,ITM升高组180例,比较2组患者实验室检测指标,进行Logistic回归分析,并将RDW与IMT进行相关分析.结果 IMT升高组较IMT正常组患者年龄更大[（62.2±9.5）岁比（53.9±9.6）岁],患高血压者比例更高[61.7%（111/180）比31.1%（14/45）],血肌酐更高[（65.3±30.8）μmol/L比（52.4±15.7）μmol/L],且RDW值更高[（13.3±0.9）%vs（12.7±0.6）%],上述4个因素的差异均具有统计学意义（均P＜0.01）.Logistic回归显示,RDW是IMT升高的危险因素之一（OR=2.272,95% CI 1.241～4.195,P=0.008）.RDW与IMT存在显著相关性（r=0.280,P=0.000）.结论 RDW与T2DM患者IMT存在密切的相关性,可能对于T2DM患者的预后判断有一定用价值.
Objective To evaluate the relationship between red cell volume distribution width（RDW） and intima media thickness（IMT） in type 2 diabetes mellitus（T2DM） patients. Methods Two hundred and twentyfive T2DM patients consecutively admitted into our hospital were divided into two groups according to whether IMT were increased or not. The baseline clinical data of the patients were collected and the relationship between RDW and IMT was evaluated. Results The age of the IMT increased group was higher than that of normal IMT group [（62.2 ± 9. 5） years vs （53. 9 ± 9. 6） years]. The proportion of patients with hypertension was higher[61.7% （111/180） vs 31.1%（14/45）] and serum creatinine was higher[（65.3 ±30.8） μmol/L vs （52.4 ± 15.7）μmol/L]. There were significant differences of age, plasma creatinine, RDW and hypertension history between the two groups （P=0.000, 0.001, 0.000, 0.000 respectively）. There was significant correlation between RDW and IMT（r= 0.28, P = 0. 000）. Logistic regression analysis indicated that RDW was one of the risk factors of IMT （OR = 2.272, 95% CI 1.241 -4.195, P=0.008）. Conclusion RDW may be significantly related to IMT in T2DM patients and may be valuable to the prognosis.
出处
《中国医药》
2011年第8期930-932,共3页
China Medicine
基金
武警医学院科研立项项目（WYM201004）
关键词
2型糖尿病
红细胞体积分布宽度
颈动脉内中膜厚度
Type 2 diabetes mellitus
Red cell volume distribution width
Intima media thickness
