摘要
目的分析2009—2010年广东省手足口病流行特征。方法收集2009—2010年广东省疾病监测报告信息系统报告的手足口病病例资料及突发公共卫生事件报告管理信息系统报告的手足口病聚集性疫情资料进行描述性流行病学分析。结果 2009和2010年广东省分别报告手足口病病例93 078和226 620例,报告死亡病例22和63例,发病率为97.53/10万和235.13/10万,死亡率0.02/10万和0.07/10万。2年度发病率居前5位的地市以珠江三角洲地区(珠海、中山、东莞、佛山市)及惠州市为主;2年度手足口病报告病例在4—7月和9—10月呈现2个高峰期(前者为全年高峰期),死亡病例在4—7月呈现高峰期;2年度报告的手足口病病例以3岁及以下儿童为主(2009、2010年分别占78.71%和81.04%),死亡病例均为5岁及以下儿童;2年度男女发病率性别比分别为1.81∶1.00、1.74∶1.00,死亡率性别比分别为1.67∶1.00、2.58∶1.00;2年度手足口病报告病例均以散居儿童为主,分别占72.21%和73.96%。2年全省报告手足口病10例及以上聚集性疫情分别为29、39起,平均罹患率分别为1.47%、4.86%。2009年报告实验室确诊病例2 889例,柯萨奇病毒A组16型(CoxA16)感染病例构成比最高(49.57%,1 432/2 889),2010年报告实验室确诊病例5 355例,肠道病毒71型(EV71)感染病例构成比最高(55.41%,2 967/5 355)。2009年报告的22例死亡病例均为感染EV71的实验室确诊病例,2010年报告实验室确诊的57例死亡病例中,EV71感染病例构成比为94.74%(54/57)。结论 2010年广东省手足口病流行强度大于2009年,2009—2010年手足口病流行优势毒株发生转变。做好社区3岁及以下散居儿童手足口病防控工作是当前手足口病防控工作的重中之重。
Objective To analyze the epidemiological characteristics of hand-foot-mouth disease （HFMD） in Guangdong from 2009 to 2010. Methods A descriptive epidemiologic analysis was made on the data of HFMD cases and outbreaks, documented by the Infectious Disease Reporting Information System and the Public Health Emergency Reporting and Information Management System in Guangdong from 2009 to 2010. Results A total of 22 deaths in 93 078 HFMD cases and 63 deaths in 226 620 HFMD cases were reported in Guangdong in 2009 and 2010, respectively. The morbidity rates were 97. 53 per 100 000 in 2009 and 235. 13 per 100 000 in 2010. The mortality rates were 0. 02 per 100 000 in 2009 and 0. 07 per 100 000 in 2010. The top five cities of reported morbidity were found in the Pearl River Delta region （4 cities） and in Huizhou from 2009 to 2010. Two peaks of incidence happened in the periods of April to July and September to October （the former period was the peak of the whole year）. The fatal case peak was observed during April to July from 2009 to 2010. The children younger than 3 years old accounted for 78. 71% of the total reported cases in 2009 and 81.04% in 2010, and the death cases were exclusively children of 5 years old or younger. The male-to-female ratios of morbidity were 1.81 ： 1.00 in 2009 and 1.74：1.00 in 2010. The HFMD cases were mainly scattered children, accounting for 72. 21% and 73.96% in 2009 and 2010, respectively. There were 29 outbreaks （ morbidity, 1.47% ） in 2009 and 39 outbreaks （morbidity, 4. 86% ） in 2010. A toal of 2 889 laboratory confirmed cases were reported in 2009, of which the cases caused by coxsackie virus A 16 （CoxA16） accounted for 49. 57% （ 1 432/2 889）, ranking first of all strains. A total of 5 355 laboratory confirmed cases were reported in 2010, 55.41% （2 967/5 355）of which were caused by enterovirus 71 （ EV71 ）. In the death cases, the EV71 positive rates were 100% （22/22） in 2009 and 94. 74% （54/57） in 2010. Conclusion The epidemic strength of HFMD was stronger in 2010 than in 2009. The major causative virus strain was different between 2009 and 2010. Thus, intensified prevention and control of HFMD epidemic is needed in the scattered children younger than 3 years of age.
出处
《华南预防医学》
2011年第4期9-13,共5页
South China Journal of Preventive Medicine
基金
广东省医学科研项目(C2010016)
