摘要
目的：观察高频喷射通气（HFJV）联合4种药物治疗海水淹溺肺水肿（PE-SWD）的效果并探讨其作用机制。方法：用海水灌注的方法诱导PE-SWD模型，采用HFJV联合地塞米松、东莨菪碱、尼莫地平和果糖二磷酸钠4种药物进行治疗，观察记录相关的生理、生化指标。结果：HFJV联合4种药物治疗能明显改善PE-SWD相关指标。结论：HFJV联合4种药物治疗能有效治疗PE-SWD，可作为其基础治疗。
Objective To observe the effects of high-frequency jet ventilation(HFJV) combinedwith four kinds of drugs in the treatment of pulmonary edema after seawater drowning (PE-SWD) in rab-bits and to explore their mechanisms of action. Methods: The models of PE-SWD were induced by infus-ing seawater into the rabbits ' lungs. Then they were treated with HFJV, dexamethasone, scopolamine,nimodipine and fructose diphosphate. The relevant indexes of physiology and biochemistry were measuredand recorded. Results: HFJV combined with the above drugs could obviously improve the indexes of PE-SWD in rabbits. Conclusion: The combined strategy has proved to be effective in the treatment of PE-SWD in rabbits, and can be used as a basic therapy.
出处
《南京军医学院学报》
1999年第4期204-206,共3页
Journal of Nanjing Military Medical College
基金
总后科研基金资助!96 M036
关键词
海水淹溺
肺水肿
高频喷射通气
药物治疗
兔
seawater drowning
pulmonary edema
high-frequency jet ventilation
medication
rabbits
