摘要
目的 研究丙烯腈对小鼠精子生成的影响。方法 经皮下注射丙烯腈35 天, 检测雄性小鼠的精子数量、活动度、精子畸形率。结果 剂量达6mg·kg -1bw 时, 小鼠精子活动度即受影响, 且随染毒剂量增加直线运动精子数明显减少(r = - 0-57 , P< 0-01) , 静止精子数增加( r= 0-30 , P< 0-05) ; 精子畸形率亦增高, 且存在剂量效应关系(r = 0-52 ; P< 0-01) 。结论 丙烯腈对小鼠的精子生成和发育具有一定的损害作用。
Objective To study the effect of acrylonitrile on the spermioteleosis in mice.Method The amount, motility and deformity of sperm of mice were determinded 35 days later after Sc.injection of acrylonitrile.Result At the level of 6mg/kg,the sperm motility was affected significantly,the number of sperm moving straightly was decreased with the increase of acrylonitrile dose(r= -0 57, P<0 01),while the amount of inactive sperms increased (r=0 30,P<0 05),and the rate of sperm deformity rate of sperm increased with a dose effect relationship(r=0 52,P<0 01).Conclusion Acrylonitrile can damage spermatogenesis in mice.
出处
《中国工业医学杂志》
CAS
1999年第6期323-334,共12页
Chinese Journal of Industrial Medicine