摘要
目的通过难治性抑郁症与非难治性抑郁症患者甲状腺激素水平的检测与比较,探讨甲状腺激素治疗难治性抑郁症的依据。方法选取难治性抑郁症患者和非难治性抑郁症患者各32例,采用放射免疫法测定两组血清TSH,T3,FT3,T4,FT4水平。结果难治性抑郁症组异常者18例,占56.25%,非难治性抑郁症组异常者5例,占15.63%。两组比较有统计学意义(χ2=11.47,P<0.005),难治性抑郁症患者组甲状腺激素水平异常率明显高于非难治性抑郁症组,表现为TSH上升(χ2=5.13,P<0.05),T3下降(χ2=5.14,P<0.05),FT4下降(χ2=5.14,P<0.05)。结论难治性抑郁症患者中有56.25%可考虑亚临床型甲状腺功能减退,甲状腺激素合并抗抑郁药治疗难治性抑郁症是有价值的可选方案。
Objective To investigate foundation that patients with refractory depression were treated with thyroid hormone by the detection and comparison of thyroid hormones level of the patients with refractory depression and single depression.Methods A total of 32 pationts with refractory depression were measured for serum thyronine stimulating hormone（TSH）,total triiodothyronine（T3）,total thyroxine（T4）,free triiodothyronine（FT3） and free thyroxine（FT4） by Radio-immunnity before treatment.Simulaneously,32 single depression matched in sex and age were recruited as controls.Results There were 18（56.25%）pationts with refractory depression whose serum thyroid hormones level was abnormal which represented as TSH up regulation（χ^2=5.13,P〈0.05）,T3（χ^2=5.14,P〈0.05） and FT4 （χ^2=5.14,P〈0.05）down regulation,and there were only 5（15.63%） abnormal in the controls.There were significant differences between the two groups（χ^2=11.47,P〈0.05）.Conclusion There is sub-clinnical thyroid function impairment in 56.25% pationts with refractory depression.That thyroid hormones combined with antidepressants drugs provide valuable treatment options for the therapy of the pationts with refractory depression.
出处
《中国健康心理学杂志》
2011年第8期919-920,共2页
China Journal of Health Psychology
