摘要
二氢吡啶类钙拮抗剂是目前临床应用最广泛的抗高血压药物之一,但该类药物大多存在水溶性差和半衰期短等缺点。为此,研究人员尝试通过制剂学手段对该类药物的水溶性及半衰期等参数进行改进,并获得了一定成果。介绍了国内外有关二氢吡啶类钙拮抗剂的药物剂型研究进展,旨在为该类溶解性不佳或半衰期较短的药物的制剂开发提供一定参考。
Dihydropyridine calcium channel antagonists are one kind of the most widely used drugs for the treatment of hypertension, but most of them have a poor water solubility and short in vivo halflife. Recently, many scientists have been trying to improve the water solubility and half-life of these drugs by means of pharmaceutical methods, and have obtained the remarkable achievements. The recent progresses in research on the dosage forms of dihydropyridine calcium channel antagonists were introduced in this paper, so as to provide a reference for the new preparations development of the drugs having poor water solubility or short half-life.
出处
《药学进展》
CAS
2011年第8期360-366,共7页
Progress in Pharmaceutical Sciences
关键词
二氢吡啶类钙拮抗剂
剂型
水难溶性药物
生物利用度
缓控释制剂
dihydropyridine calcium channel antagonist
dosage form
poor water soluble drug
bioavailability
sustained and controlled release preparation
