摘要
目的了解普通育龄夫妇中AsAb和EMAb阳性表达率及其影响阳性表达的分布状况和原因。方法应用ELISA法检测3100对参与孕前检查夫妇的血清AsAb和EMAb，并结合病史资料进行分析。结果AsAb在普通育龄男性中的阳性表达率为4．20％（130／3100）；在普通育龄女性中的阳性表达率为5．71％（177／3100）；EMAb在普通育龄女性中的阳性表达率为14．71％（456／3100）。AsAb的阳性表达在男性与高年龄、大龄初婚、性生活频率、多性伴史、刺激性饮食习惯以及生殖道感染因素有关，在女性与结婚年限、非屏障的避孕措施、多次人流、自然流产和习惯性流产及生殖道感染有关。结论AsAb、EMAb和不孕不育、自然流产以及习惯性流产等不良生育结局密切相关，普通育龄人群中的阳性表达情况及其分布特点有助于临床的正确诊断和预防治疗。
Objectives To investigate the levels of serum AsAb and EMAb in ordinary fertile period and explore its clinical significance. Methods Levels of serum AsAb and EMAb in 3 100 pre-pregnancy couples were detected by ELISA. Results The rates of elevated serum AsAb in ordinary fertile period men and women were 4.20%（130/ 3 100）and 5.71%（177/3 100）respectively. The rates of elevated serum EMAb in ordinary fertile period women was 14.71%（456/3 100）. For ordinary fertile period men,high serum AsAb level was associated with age, age at first marriage, frequency of sexual activity, history of multiple sex partners, eating habits and reproductive tract infection. For ordinary fertile period women, high serum AsAb level was related to time after marriage, non-barrier contraceptive measures, reproductive tract infections and surgery times of the abortion, spontaneous abortion and habitual abortion. Conclusion AsAb and EMAb might be associated with the infertility, spontaneous abortion and habitual abortion. The levels of serum AsAb and EMAb in the general population of fertile period couples might contribute to the clinical diagnosis and treatment.
出处
《中国男科学杂志》
CAS
CSCD
2011年第7期32-37,共6页
Chinese Journal of Andrology
