摘要
目的:测定肺栓塞患者血浆蛋白C及蛋白S的表达,探讨其联合检测在临床中的意义。方法:肺栓塞患者132例为观察组,体检正常成人132例为正常组,均检测血清中血浆蛋白C及蛋白S的表达,分析其不同预后与血浆蛋白C及S的差异及二者间的相关性。结果:与正常组比较,观察组患者血清中血浆蛋白C及蛋白S均呈明显低表达,其中死亡病例更低于好转病例,好转病例明显低于治愈病例(P<0.05,0.01);线性相关分析,血清中血浆蛋白C与蛋白S的表达呈正相关。结论:血浆蛋白C及蛋白S在肺栓塞患者血清中均呈低表达,且与预后有关,早期检测血浆蛋白C及蛋白S可能对判断肺栓塞的病情及指导治疗有重要价值。
Objective：To study the expression of protein C and protein S in serum of patients with pulmonary embolism.Methods：132 patients with pulmonary embolism served as observation group and 132 normal adults as control group.The expression levels of serum protein C and protein S were detected by ELISA.The relationship between the expression of protein C and protein S with clinical prognosis was analyzed.Results：The expression levels of serum protein C and protein S were obviously lower in observation group than in control group.The expression levels of serum protein C and protein S were obviously correlated with different treatment outcome in observation group.There was a positive correlation between protein C and protein S in the observation group.Conclusion：The expression level of protein C and protein S is lower in the patients with pulmonary embolism,and is correlated with prognosis.The early detection of protein C and protein S is helpful to predict the severity of patients with pulmonary embolism.
出处
《中国康复》
2011年第4期267-268,共2页
Chinese Journal of Rehabilitation
