摘要
目的探讨子宫颈癌患者手术治疗前放疗对血清血管内皮生长因子(VEGF)、鳞状细胞癌抗原(SCC-Ag)水平的影响。方法选择我院肿瘤科子宫颈癌患者65例,随机分为观察组(33例)和对照组(32例),对照组行单纯手术治疗,观察组在手术前进行放疗,对比分析两组患者治疗前后的血清VEGF、SCC-Ag变化及近期预后情况。结果观察组和对照组术后血清VEGF、SCC-Ag含量均较治疗前降低,差异有统计学意义(P<0.05或P<0.01),且观察组优于对照组(P<0.05);观察组近期生存率为90.91%,优于对照组的71.88%(P<0.05),但两组之间并发症发生率差异无统计学意义(P>0.05)。结论术前放疗可明显降低子宫颈癌患者血清VEGF、SCC-Ag水平,且预后较好。
Objective To explore the effects of preoperative radiotherapy for serum vascular endothelial growth factor （ VEGF ）, squamous cell carcinoma antigen （ SCC-Ag ） in patients with carcinoma of uterine cervix. Methods All 65 cases with carcinoma of uterine cervix in oncology department of our hospital were randomly divided into observation group （ 33 cases ） and control group （ 32 cases ）. The control group treated only with operation.The observation group treated with preoperative radiotherapy.Comparative analysis the serum VEGF, SCC-Ag of two group patients before and after treatment. Results The serum VEGF, SCC-Ag of two groups after operation were decline than pretherapy, and was statistically significant difference （P 〈 0.05 or P 〈 0.01 ）.The observation group was better than control group （P 〈 0.05 ）.The recent survival rate in observation group was 90.91% which was better than 71.88% in cohtrol group （P 〈 0.05 ）. There was no significant difference for complication in these two groups （P 〉 0.05 ）.Conclusion Preoperative radiotherapy can clear reduce the level of serum VEGF, SCC-Ag in patients with carcinoma of uterine cervix, and the prognosis is well.
出处
《中国现代医生》
2011年第25期73-74,共2页
China Modern Doctor
关键词
子宫颈癌
放射治疗
手术
血管内皮生长因子
鳞状细胞癌抗原
Carcinoma of uterine cervix
Radiotherapy
Operation
Vascular endothelial growth factor
Squamous cell carcinomaantigen
