摘要
目的评价小剂量右美托咪定在整形美容手术中应用的安全性和有效性。方法 60名接受整形美容手术患者随机分成两组。实验组静脉推注右美托咪定负荷剂量0.5μg/Kg,维持剂量0.1～0.5μg/Kg.h以达到镇静警觉评分(OAA/S)≤4,对照组推注等量的生理盐水。若OAA/S>4,则予咪达唑仑,另予芬太尼止痛。至OAA/S≤4开始局麻手术。术中按需追加咪达唑仑和芬太尼。结果实验组的咪达唑仑和芬太尼用量较对照组明显减少(P<0.05),术中高血压、心动过速和呼吸抑制的发生率降低(P<0.05),低血压和心动过缓的发生率无明显差异(P>0.05)。结论小剂量右美托咪定可降低咪达唑仑和芬太尼的用量,血流动力学更稳定,无明显呼吸抑制,可安全有效地用于整形美容局麻手术。
Objective To evaluated patients undergoing aesthetic surgery the satety and efficacy of small dose of dexmedetomidine （DEX） for sedation of Methods Sixty patients were given DEX 0.5 μg/Kg followed by a maintenance infusion of 0,1-0.5 μg/Kg.h （experimental group）, or equivalent volume of saline （control group）, so as to reach tile level of sedation [the Observer＇s Assessment of Alertness/Sedation Scale（OAA/S）≤4]. Midazolam was given when OAA/S〉4, followed by tentanyl injection for analgesia. When OAA/S ≤4, the operation began. Midazolam and fentanyl were given if necessary during the operation. Results DEX group required hess fentanyl （P〈0.05） and less midazolam （P〈0.05） compared with the saline group. The incidence of hypertension, tachycardia and significant respiratory depression was lower in DEX-treated patients versus placebo （P〈0.05）. The incidence of hypotension and bradycardia was similar in DEX-treated patients versus placebo （P〉0.05）. Conclusion DEX is an effective baseline sedative tot patients undergoing aesthetic surgeries providing less anesthetic dose of midazolam and fentanyl, more hemodynamic stability, and less respiratory depression.
出处
《组织工程与重建外科杂志》
2011年第4期228-230,共3页
Journal of Tissue Engineering and Reconstructive Surgery
关键词
整形美容手术
右美托咪定
镇静
镇痛
Aesthetic surgery
Dexmedetomidine
Sedation
Analgesia
